Recombinant Human PDGF-DD Protein | R&D Systems 1159-SB-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PDGF-DD Protein

catalog :

1159-SB-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 19

Reference
Wong K, Cheng Y, Wu V, Kiseleva A, Li J, Poleshko A, et al. Growth factor-induced activation of MSK2 leads to phosphorylation of H3K9me2S10 and corresponding changes in gene expression. Sci Adv. 2024;10:eadm9518 pubmed publisher
Kim H, Cheng P, Travisano S, Weldy C, Monteiro J, Kundu R, et al. Molecular mechanisms of coronary artery disease risk at the PDGFD locus. Nat Commun. 2023;14:847 pubmed publisher
Akiyama T, Yasuda T, Uchihara T, Yasuda Yoshihara N, Tan B, Yonemura A, et al. Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors. Cancer Res. 2023;83:753-770 pubmed publisher
Pham T, Najy A, Kim H. E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR. J Biol Chem. 2022;298:101981 pubmed publisher
Li Z, Yu S, Liu Y, Hu X, Li Y, Xiao Z, et al. SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway. J Neuroinflammation. 2022;19:95 pubmed publisher
Kim J, Baek S, Jeon E, Choi J, Jang E, Kim C. PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells. PLoS ONE. 2022;17:e0265191 pubmed publisher
Ma S, Tang T, Wu X, Mansour A, Lu T, Zhang J, et al. PDGF-D-PDGFRβ signaling enhances IL-15-mediated human natural killer cell survival. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
Yamamoto Y, Mukai A, Ikushima T, Urata Y, Kinoshita S, Hamuro J, et al. Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model. Sci Rep. 2020;10:20936 pubmed publisher
Mamer S, Chen S, Weddell J, Palasz A, Wittenkeller A, Kumar M, et al. Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics. Sci Rep. 2017;7:16439 pubmed publisher
Miller C, Pjanic M, Wang T, Nguyen T, Cohain A, Lee J, et al. Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. Nat Commun. 2016;7:12092 pubmed publisher
Heim E, Marston J, Federman R, Edwards A, Karabadzhak A, Petti L, et al. Biologically active LIL proteins built with minimal chemical diversity. Proc Natl Acad Sci U S A. 2015;112:E4717-25 pubmed publisher
Obenauf A, Zou Y, Ji A, Vanharanta S, Shu W, Shi H, et al. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 2015;520:368-72 pubmed publisher
Petti L, Talbert Slagle K, Hochstrasser M, DiMaio D. A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor ? receptor into an inhibitor. J Biol Chem. 2013;288:27273-86 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Martino M, Hubbell J. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J. 2010;24:4711-21 pubmed publisher
Crawford Y, Kasman I, Yu L, ZHONG C, Wu X, Modrusan Z, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell. 2009;15:21-34 pubmed publisher
Rice J, Veal J, Fadden R, Barabasz A, Partridge J, Barta T, et al. Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis. Arthritis Rheum. 2008;58:3765-75 pubmed publisher
Wågsäter D, Zhu C, Björck H, Eriksson P. Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. Atherosclerosis. 2009;202:415-23 pubmed publisher
McCabe K, Bronner Fraser M. Essential role for PDGF signaling in ophthalmic trigeminal placode induction. Development. 2008;135:1863-74 pubmed publisher

product information

brand :

R&D Systems

master code :

1159-SB

SKU :

1159-SB-025

product name :

Recombinant Human PDGF-DD Protein

unit size :

25 ug

seo description :

The Recombinant Human PDGF-DD Protein from R&D Systems is derived from NS0. The Recombinant Human PDGF-DD Protein has been validated for the following applications: Bioactivity.

target :

PDGF-DD

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

19 kDa, reducing conditions

theoretical molecular weight :

14 kDa (monomer)

gene symbol :

PDGFD

details of functionality :

Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 15-75 ng/mL in a fluorometric assay using the redox sensitive dye, Resazurin (Catalog # AR002 ) and 2-5 ng/mL when measured by 3H-thymidine incorporation.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9GZP0.1

applications :

Bioactivity

source :

NS0-derived Recombinant Human PDGF-DD Protein

USD :

432 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage