Recombinant Human Semaphorin 6A Fc Chimera Protein, CF | R&D Systems 1146-S6-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Semaphorin 6A Fc Chimera Protein, CF

catalog :

1146-S6-025

quantity :

25 ug

price :

468 USD

citations: 7

Reference
Farah E, Hu R, Kern C, Zhang Q, Lu T, Ma Q, et al. Spatially organized cellular communities form the developing human heart. Nature. 2024;627:854-864 pubmed publisher
Tian S, Xiong X, Zeng J, Wang S, Tremblay B, Chen P, et al. Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nat Commun. 2022;13:6786 pubmed publisher
Tian X, Yan H, Li J, Wu S, Wang J, Fan L. Neurotrophin Promotes Neurite Outgrowth by Inhibiting Rif GTPase Activation Downstream of MAPKs and PI3K Signaling. Int J Mol Sci. 2017;18: pubmed publisher
Ebert A, Childs S, Hehr C, Cechmanek P, McFarlane S. Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion. Development. 2014;141:2473-82 pubmed publisher
Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, et al. Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood. 2012;120:4104-15 pubmed publisher
Tran Van H, Avota E, Börtlein C, Mueller N, Schneider Schaulies S. Measles virus modulates dendritic cell/T-cell communication at the level of plexinA1/neuropilin-1 recruitment and activity. Eur J Immunol. 2011;41:151-63 pubmed publisher
Renaud J, Kerjan G, Sumita I, Zagar Y, Georget V, Kim D, et al. Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nat Neurosci. 2008;11:440-9 pubmed publisher

product information

master code :

1146-S6

SKU :

1146-S6-025

product name :

Recombinant Human Semaphorin 6A Fc Chimera Protein, CF

unit size :

25 ug

description :

The Recombinant Human Semaphorin 6A Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Semaphorin 6A Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Semaphorin 6A

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

120 kDa, reducing conditions

theoretical molecular weight :

97 kDa (monomer)

gene symbol :

SEMA6A

details of functionality :

Measured by its ability to inhibit the proliferation of HUVEC human umbilical vein endothelial cells. Moriya, J. etáal . (2010) Circ. Res. 106 :391. The ED50 for this effect is 0.4-2.4 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9H2E6

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human Semaphorin 6A protein Human Semaphorin 6A (Gly19-Thr649) Accession # Q9H2E6 DIEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

468 USD

alt names :

KIAA1368HT018, SEMA, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A, Sema VIA, Sema6A, SEMA6A1, SEMA6A-1, semaphorin 6A-1, Semaphorin VIA, semaphorin-6A, Semaphorin-6A-1, SEMAQ, VIA

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.