Recombinant Human RAGE Fc Chimera Protein, CF | R&D Systems 1145-RG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human RAGE Fc Chimera Protein, CF

catalog :

1145-RG

quantity :

50 ug

price :

339 USD

citations: 15

Reference
Hwang J, Chu H, Ahn Y, Kim J, Kim D. HMGB1 promotes hair growth via the modulation of prostaglandin metabolism. Sci Rep. 2019;9:6660 pubmed publisher
Wang K, Shan S, Wang S, Gu X, Zhou X, Ren T. HMGB1-containing nucleosome mediates chemotherapy-induced metastasis of human lung cancer. Biochem Biophys Res Commun. 2018;500:758-764 pubmed publisher
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
Wolf D, Anto Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann J, et al. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nat Commun. 2018;9:525 pubmed publisher
Sato H, Sakaguchi M, Yamamoto H, Tomida S, Aoe K, Shien K, et al. Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma. Oncogenesis. 2018;7:11 pubmed publisher
Deng H, Wang C, Chang D, Hu N, Chen M, Zhao M. High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route. Arthritis Res Ther. 2017;19:125 pubmed publisher
Buyannemekh D, Nham S. Characterization of Î±X I-Domain Binding to Receptors for Advanced Glycation End Products (RAGE). Mol Cells. 2017;40:355-362 pubmed publisher
Stock A, Kasus Jacobi A, Wren J, Sjoelund V, Prestwich G, Pereira H. The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis. PLoS ONE. 2016;11:e0163330 pubmed publisher
Li W, Xu Q, Deng Y, Yang Z, Xing S, Zhao X, et al. High-mobility group box 1 accelerates lipopolysaccharide-induced lung fibroblast proliferation in vitro: involvement of the NF-ÎºB signaling pathway. Lab Invest. 2015;95:635-47 pubmed publisher
Augner K, Eichler J, Utz W, Pischetsrieder M. Influence of nonenzymatic posttranslational modifications on constitution, oligomerization and receptor binding of S100A12. PLoS ONE. 2014;9:e113418 pubmed publisher
Rao N, Argyle B, Xu X, Reynolds P, Walenga J, Prechel M, et al. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol. 2010;299:C97-110 pubmed publisher
Means T, Mylonakis E, Tampakakis E, Colvin R, Seung E, Puckett L, et al. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009;206:637-53 pubmed publisher
Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, et al. S100A11, an dual mediator for growth regulation of human keratinocytes. Mol Biol Cell. 2008;19:78-85 pubmed
Yammani R, Carlson C, Bresnick A, Loeser R. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006;54:2901-11 pubmed
Kiryushko D, Novitskaya V, Soroka V, Klingelhofer J, Lukanidin E, Berezin V, et al. Molecular mechanisms of Ca(2+) signaling in neurons induced by the S100A4 protein. Mol Cell Biol. 2006;26:3625-38 pubmed

product information

brand :

R&D Systems

master code :

1145-RG

SKU :

1145-RG-050

product name :

Recombinant Human RAGE Fc Chimera Protein, CF

description :

The Recombinant Human RAGE Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human RAGE Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

AGER

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

80-90 kDa, reducing conditions

theoretical molecular weight :

61 kDa (monomer)

gene symbol :

AGER

details of functionality :

Measured by its binding ability in a functional ELISA. rhRAGE/Fc Chimera immobilized at 5 µg/mL (100 µL/well) on a goat anti-human IgG Fc antibody-coated plate (0.5 µg/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA, Catalog # BT4127) with a linear range of 0.02-1 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

1145-RG

accessionNumbers :

Q15109

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human RAGE protein Human RAGE (Gln24 - Ala344) Accession # Q15109 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

alt names :

advanced glycosylation end product-specific receptor, AGER, RAGE isoform delta, RAGE isoform sRAGE-delta, Receptor for advanced glycosylation end products, receptor for advanced glycosylation end-products, SCARJ1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.