product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human RAGE Fc Chimera Protein, CF
catalog :
1145-RG-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Kasus Jacobi A, Washburn J, Laurence R, Pereira H. Selecting Multitarget Peptides for Alzheimer's Disease. Biomolecules. 2022;12: pubmed publisher
Maehara N, Taniguchi K, Okuno A, Ando H, Hirota A, Li Z, et al. AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke. Cell Rep. 2021;36:109693 pubmed publisher
Tsubokawa D, Kikuchi T, Lee J, Kusakabe T, Yamamoto Y, Maruyama H. Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration. PLoS Pathog. 2021;17:e1009649 pubmed publisher
Deng Y, Govers C, Teodorowicz M, Liobyte I, De Simone I, Hettinga K, et al. Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses. PLoS ONE. 2020;15:e0236212 pubmed publisher
Hwang J, Chu H, Ahn Y, Kim J, Kim D. HMGB1 promotes hair growth via the modulation of prostaglandin metabolism. Sci Rep. 2019;9:6660 pubmed publisher
Wang K, Shan S, Wang S, Gu X, Zhou X, Ren T. HMGB1-containing nucleosome mediates chemotherapy-induced metastasis of human lung cancer. Biochem Biophys Res Commun. 2018;500:758-764 pubmed publisher
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
Wolf D, Anto Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann J, et al. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nat Commun. 2018;9:525 pubmed publisher
Sato H, Sakaguchi M, Yamamoto H, Tomida S, Aoe K, Shien K, et al. Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma. Oncogenesis. 2018;7:11 pubmed publisher
Deng H, Wang C, Chang D, Hu N, Chen M, Zhao M. High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route. Arthritis Res Ther. 2017;19:125 pubmed publisher
Buyannemekh D, Nham S. Characterization of αX I-Domain Binding to Receptors for Advanced Glycation End Products (RAGE). Mol Cells. 2017;40:355-362 pubmed publisher
Stock A, Kasus Jacobi A, Wren J, Sjoelund V, Prestwich G, Pereira H. The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis. PLoS ONE. 2016;11:e0163330 pubmed publisher
Li W, Xu Q, Deng Y, Yang Z, Xing S, Zhao X, et al. High-mobility group box 1 accelerates lipopolysaccharide-induced lung fibroblast proliferation in vitro: involvement of the NF-κB signaling pathway. Lab Invest. 2015;95:635-47 pubmed publisher
Augner K, Eichler J, Utz W, Pischetsrieder M. Influence of nonenzymatic posttranslational modifications on constitution, oligomerization and receptor binding of S100A12. PLoS ONE. 2014;9:e113418 pubmed publisher
Rao N, Argyle B, Xu X, Reynolds P, Walenga J, Prechel M, et al. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol. 2010;299:C97-110 pubmed publisher
Means T, Mylonakis E, Tampakakis E, Colvin R, Seung E, Puckett L, et al. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009;206:637-53 pubmed publisher
Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, et al. S100A11, an dual mediator for growth regulation of human keratinocytes. Mol Biol Cell. 2008;19:78-85 pubmed
Yammani R, Carlson C, Bresnick A, Loeser R. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006;54:2901-11 pubmed
Kiryushko D, Novitskaya V, Soroka V, Klingelhofer J, Lukanidin E, Berezin V, et al. Molecular mechanisms of Ca(2+) signaling in neurons induced by the S100A4 protein. Mol Cell Biol. 2006;26:3625-38 pubmed
product information
brand :
R&D Systems
master code :
1145-RG
SKU :
1145-RG-050
product name :
Recombinant Human RAGE Fc Chimera Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human RAGE Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human RAGE Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
RAGE/AGER
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
80-90 kDa, reducing conditions
theoretical molecular weight :
61 kDa (monomer)
gene symbol :
AGER
details of functionality :
Measured by its binding ability in a functional ELISA. rhRAGE/Fc Chimera immobilized at 5 ╡g/mL (100 ╡L/well) on a goat anti-human IgG Fc antibody-coated plate (0.5 ╡g/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA, Catalog # BT4127) with a linear range of 0.02-1 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q15109
applications :
Binding Activity
source :
NS0-derived Recombinant Human RAGE Fc Chimera Protein, CF
USD :
432 USD
alt names :
advanced glycosylation end product-specific receptor, AGER, RAGE isoform delta, RAGE isoform sRAGE-delta, Receptor for advanced glycosylation end products, receptor for advanced glycosylation end-products, SCARJ1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.