Recombinant Human Siglec-9 Fc Chimera Protein, CF | R&D Systems 1139-SL-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Siglec-9 Fc Chimera Protein, CF

catalog :

1139-SL-050

quantity :

50 ug

price :

456 USD

citations: 13

Reference
Benucci B, Spinello Z, Calvaresi V, Viviani V, Perrotta A, Faleri A, et al. Neisserial adhesin A (NadA) binds human Siglec-5 and Siglec-14 with high affinity and promotes bacterial adhesion/invasion. MBio. 2024;15:e0110724 pubmed publisher
Chan C, Lustig M, Jansen J, Garcia Villagrasa L, Raymakers L, Daamen L, et al. Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9. Cancers (Basel). 2023;15: pubmed publisher
Egan H, Treacy O, Lynch K, Leonard N, O Malley G, Reidy E, et al. Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment. Cell Rep. 2023;42:112475 pubmed publisher
Adeniji O, Kuri Cervantes L, Yu C, Xu Z, Ho M, Chew G, et al. Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells. PLoS Pathog. 2021;17:e1010034 pubmed publisher
Terävä J, Tiainen L, Lamminmaki U, Kellokumpu Lehtinen P, Pettersson K, Gidwani K. Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma. PLoS ONE. 2019;14:e0219480 pubmed publisher
Haas Q, Boligan K, Jandus C, Schneider C, Simillion C, Stanczak M, et al. Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment. Cancer Immunol Res. 2019;7:707-718 pubmed publisher
Zeng Z, Li M, Wang M, Wu X, Li Q, Ning Q, et al. Increased expression of Siglec-9 in chronic obstructive pulmonary disease. Sci Rep. 2017;7:10116 pubmed publisher
Liu D, Ning Y, Liu J, Wang X, Tu R, Shen H, et al. Siglec-9 is upregulated in rheumatoid arthritis and suppresses collagen-induced arthritis through reciprocal regulation of Th17-/Treg-cell differentiation. Scand J Immunol. 2017;85:433-440 pubmed publisher
Ito T, Ishigami M, Matsushita Y, Hirata M, Matsubara K, Ishikawa T, et al. Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity. Sci Rep. 2017;7:44043 pubmed publisher
Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, et al. Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages. Arthritis Res Ther. 2016;18:133 pubmed publisher
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci. 2015;35:2452-64 pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, et al. Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. PLoS ONE. 2011;6:e24559 pubmed publisher

product information

master code :

1139-SL

SKU :

1139-SL-050

product name :

Recombinant Human Siglec-9 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human Siglec-9 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Siglec-9 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Siglec-9

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

90-100 kDa, reducing conditions

theoretical molecular weight :

62.7 kDa (monomer)

gene symbol :

SIGLEC9

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED50 for this effect is 10.0-100 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9Y336

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human Siglec-9 protein Human Siglec-9 (Gln18-Gly348) Accession # Q9Y336 DIEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

456 USD

alt names :

CD329, CDw329, FOAP-9, OBBP-Like, Protein FOAP-9, sialic acid binding Ig-like lectin 9, sialic acid-binding Ig-like lectin 9, siglec-9, Siglec9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.