Recombinant Human Siglec-7/CD328 Fc Chimera Protein, CF | R&D Systems 1138-SL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Siglec-7/CD328 Fc Chimera Protein, CF

catalog :

1138-SL-050

quantity :

50 ug

price :

468 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Bordoloi D, Kulkarni A, Adeniji O, Pampena M, Bhojnagarwala P, Zhao S, et al. Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers. Sci Adv. 2023;9:eadh4379 pubmed publisher
Chan C, Lustig M, Jansen J, Garcia Villagrasa L, Raymakers L, Daamen L, et al. Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9. Cancers (Basel). 2023;15: pubmed publisher
van Houtum E, Kers Rebel E, Looman M, Hooijberg E, B xfc ll C, Granado D, et al. Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7. Cell Mol Life Sci. 2023;80:169 pubmed publisher
Egan H, Treacy O, Lynch K, Leonard N, O Malley G, Reidy E, et al. Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment. Cell Rep. 2023;42:112475 pubmed publisher
Vijayan M, Lee C, Wong V, Wang X, Bai K, Wu J, et al. Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7. J Cell Sci. 2020;133: pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
Hudak J, Canham S, Bertozzi C. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nat Chem Biol. 2014;10:69-75 pubmed publisher
Varchetta S, Brunetta E, Roberto A, Mikulak J, Hudspeth K, Mondelli M, et al. Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes. PLoS ONE. 2012;7:e45821 pubmed publisher
Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, et al. Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. PLoS ONE. 2011;6:e24559 pubmed publisher

product information

brand :

R&D Systems

master code :

1138-SL

SKU :

1138-SL-050

product name :

Recombinant Human Siglec-7/CD328 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human Siglec-7/CD328 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Siglec-7/CD328 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Siglec-7/CD328

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and NaCl.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>85%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

90-100 kDa, reducing conditions

theoretical molecular weight :

64 kDa (monomer)

gene symbol :

SIGLEC7

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED50 for this effect is 0.5-2á╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9Y286

applications :

Bioactivity

source :

NS0-derived Recombinant Human Siglec-7/CD328 Fc Chimera Protein, CF

USD :

468 USD

alt names :

Adhesion inhibitory receptor molecule 1, adhesion inhibitory receptor molecule 1, siglec-7, AIRM1, AIRM-1, AIRM1QA79 membrane protein, CD328, CD328 antigen, CDw328, D-siglec, p75, p75/AIRM1, QA79, sialic acid binding Ig-like lectin 7, sialic acid binding immunoglobulin-like lectin 7, sialic acid-binding Ig-like lectin 7, Siglec7, Siglec-7

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage