Recombinant Human Siglec-3/CD33 Fc Chimera Protein, CF | R&D Systems 1137-SL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Siglec-3/CD33 Fc Chimera Protein, CF

catalog :

1137-SL-050

quantity :

50 ug

price :

468 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Adeniji O, Kuri Cervantes L, Yu C, Xu Z, Ho M, Chew G, et al. Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells. PLoS Pathog. 2021;17:e1010034 pubmed publisher
Terävä J, Tiainen L, Lamminmaki U, Kellokumpu Lehtinen P, Pettersson K, Gidwani K. Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma. PLoS ONE. 2019;14:e0219480 pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
Ishida A, Akita K, Mori Y, Tanida S, Toda M, Inoue M, et al. Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33. J Biol Chem. 2014;289:25341-50 pubmed publisher
Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, et al. Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. PLoS ONE. 2011;6:e24559 pubmed publisher
Robak L, Venkatesh K, Lee H, Raiker S, Duan Y, Lee Osbourne J, et al. Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. J Neurosci. 2009;29:5768-83 pubmed publisher
Hasegawa Y, Fujitani M, Hata K, Tohyama M, Yamagishi S, Yamashita T. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. J Neurosci. 2004;24:6826-32 pubmed

product information

brand :

R&D Systems

master code :

1137-SL

SKU :

1137-SL-050

product name :

Recombinant Human Siglec-3/CD33 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human Siglec-3/CD33 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Siglec-3/CD33 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Siglec-3/CD33

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

67-85 kDa, reducing conditions

theoretical molecular weight :

53.4 kDa (monomer)

gene symbol :

CD33

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED50 for this effect is 1-4á╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAA51948

applications :

Bioactivity

source :

NS0-derived Recombinant Human Siglec-3/CD33 Fc Chimera Protein, CF

USD :

468 USD

alt names :

CD33, CD33 antigen, CD33 antigen (gp67), CD33 molecule, FLJ00391, gp67, myeloid cell surface antigen CD33, p67, sialic acid binding Ig-like lectin 3, Sialic acid-binding Ig-like lectin 3, Siglec3, SIGLEC-3, SIGLEC3gp67

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage