Recombinant Human ErbB4/Her4 Fc Chimera Protein, CF | R&D Systems 1131-ER-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ErbB4/Her4 Fc Chimera Protein, CF

catalog :

1131-ER-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Yun M, Kim D, Lee J, Kim H, Kim H, Pyo A, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017;7:2620-2633 pubmed publisher
Parry T, Ganguly A, Troy E, Luis Guerrero J, Iaci J, Srinivas M, et al. Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction. Eur J Pharmacol. 2017;796:76-89 pubmed publisher
Leung I, Jarvik N, Sidhu S. A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents. J Mol Biol. 2017;429:115-127 pubmed publisher
Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, et al. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Mol Ther. 2015;23:1722-1733 pubmed publisher
Iaci J, Ganguly A, Finklestein S, Parry T, Ren J, Saha S, et al. Glial growth factor 2 promotes functional recovery with treatment initiated up to 7 days after permanent focal ischemic stroke. Neuropharmacology. 2010;59:640-9 pubmed publisher
Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjöberg A, Larsson B, et al. Design of an optimized scaffold for affibody molecules. J Mol Biol. 2010;398:232-47 pubmed publisher
Hamra F, Chapman K, Nguyen D, Garbers D. Identification of neuregulin as a factor required for formation of aligned spermatogonia. J Biol Chem. 2007;282:721-30 pubmed

product information

brand :

R&D Systems

master code :

1131-ER

SKU :

1131-ER-050

product name :

Recombinant Human ErbB4/Her4 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human ErbB4/Her4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ErbB4/Her4 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ErbB4/Her4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

122-132 kDa, reducing conditions

theoretical molecular weight :

97 kDa (monomer)

gene symbol :

ERBB4

details of functionality :

Measured by its ability to inhibit the biological activity of Neuregulin-1┐▀1 on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 1.5-6 ╡g/mL in the presence of 10 ng/mL of Recombinant Human NRG1┐▀1/HRG1┐▀1 Extracellular Domain (Catalog # 377-HB ).

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q15303

applications :

Bioactivity

source :

NS0-derived Recombinant Human ErbB4/Her4 Fc Chimera Protein, CF

USD :

432 USD

alt names :

avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, EC 2.7.10, EC 2.7.10.1, HER4, HER4MGC138404, p180erbB4, Proto-oncogene-like protein c-ErbB-4, receptor tyrosine-protein kinase erbB-4, Tyrosine kinase-type cell surface receptor HER4, v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage