Recombinant Human Dkk-3 Protein, CF | R&D Systems 1118-DK product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Dkk-3 Protein, CF

catalog :

1118-DK

quantity :

50 ug

price :

329 USD

citations: 5

Reference
Cheng J, Brown T, Murtha T, Stenman A, Juhlin C, Larsson C, et al. A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis. BMC Cancer. 2017;17:164 pubmed publisher
Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, et al. Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq. PLoS ONE. 2016;11:e0154531 pubmed publisher
Zhu Y, Demidov O, Goh A, Virshup D, Lane D, Bulavin D. Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest. 2014;124:3263-73 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Untergasser G, Steurer M, Zimmermann M, Hermann M, Kern J, Amberger A, et al. The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation. Int J Cancer. 2008;122:1539-47 pubmed

product information

brand :

R&D Systems

master code :

1118-DK

SKU :

1118-DK-050

product name :

Recombinant Human Dkk-3 Protein, CF

description :

The Recombinant Human Dkk-3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Dkk-3 Protein, CF has been validated for the following applications: Bioactivity.

target :

Dkk-3

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

75-80 kDa, reducing conditions

theoretical molecular weight :

37.5 kDa

gene symbol :

DKK3

details of functionality :

Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. Hsieh, S.Y. et al . (2004) Oncogene 23 :9183. The ED50 for this effect is 3-12 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

1118-DK

accessionNumbers :

Q9UBP4.1

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human Dkk-3 protein Ala22-Ile350, with a C-terminal 10-His tag

2020 USD :

329

2021 USD :

329 USD

alt names :

dickkopf (Xenopus laevis) homolog 3, dickkopf 3, dickkopf homolog 3 (Xenopus laevis), Dickkopf-3, dickkopf-related protein 3, Dkk3, Dkk-3, hDkk-3, regulated in glioma, REIC, REICdkk-3, RIG, RIG-like 5-6, RIG-like 7-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.