Recombinant Human Dkk-3 Protein, CF | R&D Systems 1118-DK-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Dkk-3 Protein, CF

catalog :

1118-DK-050

quantity :

50 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Li Y, Wei Y, Ultsch M, Li W, Tang W, Tombling B, et al. Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region. Nat Commun. 2024;15:4359 pubmed publisher
Martín Flores N, Podpolny M, McLeod F, Workman I, Crawford K, Ivanov D, et al. Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model. elife. 2024;12: pubmed publisher
Ruscitto A, Chen P, Tosa I, Wang Z, Zhou G, Safina I, et al. Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity. Cell Stem Cell. 2023;30:1179-1198.e7 pubmed publisher
Cooney R, Saal M, Geraci K, Maynard C, Cleaver O, Hoang O, et al. A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis. J Cell Sci. 2023;136: pubmed publisher
Gerhardy S, Ultsch M, Tang W, Green E, Holden J, Li W, et al. Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nat Commun. 2022;13:5222 pubmed publisher
Nie X, He F, Lan C, Niu J, Xia P. Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients. Onco Targets Ther. 2021;14:427-434 pubmed publisher
Tom I, Pham V, Katschke K, Li W, Liang W, Gutierrez J, et al. Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy. Proc Natl Acad Sci U S A. 2020;117:9952-9963 pubmed publisher
Cheng J, Brown T, Murtha T, Stenman A, Juhlin C, Larsson C, et al. A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis. BMC Cancer. 2017;17:164 pubmed publisher
Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, et al. Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq. PLoS ONE. 2016;11:e0154531 pubmed publisher
Zhu Y, Demidov O, Goh A, Virshup D, Lane D, Bulavin D. Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest. 2014;124:3263-73 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Untergasser G, Steurer M, Zimmermann M, Hermann M, Kern J, Amberger A, et al. The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation. Int J Cancer. 2008;122:1539-47 pubmed

product information

brand :

R&D Systems

master code :

1118-DK

SKU :

1118-DK-050

product name :

Recombinant Human Dkk-3 Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human Dkk-3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Dkk-3 Protein, CF has been validated for the following applications: Bioactivity.

target :

Dkk-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

64-74 kDa, reducing conditions

theoretical molecular weight :

37.5 kDa

gene symbol :

DKK3

details of functionality :

Measured by its ability to inhibit proliferation of HeLa human cervical epithelial carcinoma cells. Hsieh, S.Y. et al . (2004) Oncogene 23 :9183. The ED50 for this effect is 3-12 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9UBP4.1

applications :

Bioactivity

source :

NS0-derived Recombinant Human Dkk-3 Protein, CF

USD :

400 USD

alt names :

dickkopf (Xenopus laevis) homolog 3, dickkopf 3, dickkopf homolog 3 (Xenopus laevis), Dickkopf-3, dickkopf-related protein 3, Dkk3, Dkk-3, hDkk-3, regulated in glioma, REIC, REICdkk-3, RIG, RIG-like 5-6, RIG-like 7-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage