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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Netrin-1 Protein, CF
catalog :
1109-N1-025/CF
quantity :
25 ug
price :
432 USD
more info or order :
citations: 38
Reference
Ramalingam P, Gutkin M, Poulos M, Tillery T, Doughty C, Winiarski A, et al. Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response. Nat Commun. 2023;14:2018 pubmed publisher
Xia X, Mao Z, Wang W, Ma J, Tian J, Wang S, et al. Netrin-1 Promotes the Immunosuppressive Activity of MDSCs in Colorectal Cancer. Cancer Immunol Res. 2023;11:600-613 pubmed publisher
Zang Y, Chaudhari K, Bashaw G. Tace/ADAM17 is a bi-directional regulator of axon guidance that coordinates distinct Frazzled and Dcc receptor signaling outputs. Cell Rep. 2022;41:111785 pubmed publisher
Chan E, Ge Y, So Y, Bai Y, Liu L, Wang Y. Allosteric potentiation of GABAA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis. Cell Rep. 2022;41:111584 pubmed publisher
Wei H, Ailanen L, Morales M, Koivisto A, Pertovaara A. Spinal TRPA1 Contributes to the Mechanical Hypersensitivity Effect Induced by Netrin-1. Int J Mol Sci. 2022;23: pubmed publisher
Barroca V, Racine C, Pays L, Fouchet P, Coureuil M, Allemand I. The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice. Stem Cell Res. 2022;60:102723 pubmed publisher
Boyé K, Geraldo L, Furtado J, Pibouin Fragner L, Poulet M, Kim D, et al. Endothelial Unc5B controls blood-brain barrier integrity. Nat Commun. 2022;13:1169 pubmed publisher
Pradella D, Deflorian G, Pezzotta A, di Matteo A, Belloni E, Campolungo D, et al. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis. Nat Commun. 2021;12:4872 pubmed publisher
Chen G, Kang S, Wang Z, Ahn E, Xia Y, Liu X, et al. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Sci Adv. 2021;7: pubmed publisher
Shigeoka T, Koppers M, Wong H, Lin J, Cagnetta R, Dwivedy A, et al. On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons. Cell Rep. 2019;29:3605-3619.e10 pubmed publisher
Pignata A, Ducuing H, Boubakar L, Gardette T, Kindbeiter K, Bozon M, et al. A Spatiotemporal Sequence of Sensitization to Slits and Semaphorins Orchestrates Commissural Axon Navigation. Cell Rep. 2019;29:347-362.e5 pubmed publisher
Shao Q, Yang T, Huang H, Majumder T, Khot B, Khouzani M, et al. Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling. PLoS ONE. 2019;14:e0218811 pubmed publisher
Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, et al. The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Res. 2019;47:4765-4777 pubmed publisher
He X, Liu Y, Lin X, Yuan F, Long D, Zhang Z, et al. Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice. J Neuroinflammation. 2018;15:268 pubmed publisher
Zhang Y, Chen P, Di G, Qi X, Zhou Q, Gao H. Netrin-1 promotes diabetic corneal wound healing through molecular mechanisms mediated via the adenosine 2B receptor. Sci Rep. 2018;8:5994 pubmed publisher
Sato T, Kokabu S, Enoki Y, Hayashi N, Matsumoto M, Nakahira M, et al. Functional Roles of Netrin-1 in Osteoblast Differentiation. In Vivo. 2017;31:321-328 pubmed
Yamahara K, Nakagawa T, Ito J, Kinoshita K, Omori K, Yamamoto N. Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells. Neuropharmacology. 2017;119:26-39 pubmed publisher
Glendining K, Markie D, Gardner R, Franz E, Robertson S, Jasoni C. A novel role for the DNA repair gene Rad51 in Netrin-1 signalling. Sci Rep. 2017;7:39823 pubmed publisher
Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M. An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid ? Precursor Protein Signaling. J Biol Chem. 2016;291:12282-93 pubmed publisher
Ros O, Cotrufo T, Martínez Mármol R, Soriano E. Regulation of patterned dynamics of local exocytosis in growth cones by netrin-1. J Neurosci. 2015;35:5156-70 pubmed publisher
Deming P, Campbell S, Stone J, Rivard R, Mercier A, Howe A. Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). J Biol Chem. 2015;290:5783-96 pubmed publisher
Mediero A, Ramkhelawon B, Perez Aso M, Moore K, Cronstein B. Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res. 2015;30:837-54 pubmed publisher
O Leary C, Bradford D, Chen M, White A, Blackmore D, Cooper H. The Netrin/RGM receptor, Neogenin, controls adult neurogenesis by promoting neuroblast migration and cell cycle exit. Stem Cells. 2015;33:503-14 pubmed publisher
Lu X, Kim Han J, Harmon S, Sakiyama Elbert S, O Malley K. The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons. Mol Neurodegener. 2014;9:17 pubmed publisher
Ramkhelawon B, Hennessy E, Ménager M, Ray T, Sheedy F, Hutchison S, et al. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med. 2014;20:377-84 pubmed publisher
Chen J, Cai Q, Shen P, Yan R, Wang C, Yang D, et al. Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice. PLoS ONE. 2012;7:e46201 pubmed publisher
Palmesino E, Haddick P, Tessier Lavigne M, Kania A. Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates. J Neurosci. 2012;32:411-6 pubmed publisher
Kim Han J, Antenor Dorsey J, O Malley K. The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. J Neurosci. 2011;31:7212-21 pubmed publisher
Kuwako K, Kakumoto K, Imai T, Igarashi M, Hamakubo T, Sakakibara S, et al. Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression. Neuron. 2010;67:407-21 pubmed publisher
Tadagavadi R, Wang W, Ramesh G. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol. 2010;185:3750-8 pubmed publisher
Mancino M, Esposito C, Watanabe K, Nagaoka T, Gonzales M, Bianco C, et al. Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells. Cancer Res. 2009;69:1717-21 pubmed publisher
Rosenberger P, Schwab J, Mirakaj V, Masekowsky E, Mager A, Morote Garcia J, et al. Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol. 2009;10:195-202 pubmed publisher
Wu T, Li W, Li H. Netrin-1 attenuates ischemic stroke-induced apoptosis. Neuroscience. 2008;156:475-82 pubmed publisher
Schaffar G, Taniguchi J, Brodbeck T, Meyer A, Schmidt M, Yamashita T, et al. LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin. J Neurochem. 2008;107:418-31 pubmed publisher
Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth B, et al. Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol. 2008;216:824-34 pubmed publisher
Wang W, Reeves W, Ramesh G. Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am J Physiol Renal Physiol. 2008;294:F739-47 pubmed publisher
Isakova I, Baker K, DuTreil M, Dufour J, Gaupp D, Phinney D. Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells. 2007;25:3261-70 pubmed
Nguyen A, Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci U S A. 2006;103:6530-5 pubmed
product information
brand :
R&D Systems
master code :
1109-N1/CF
SKU :
1109-N1-025/CF
product name :
Recombinant Mouse Netrin-1 Protein, CF
unit size :
25 ug
seo description :
The Recombinant Mouse Netrin-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Netrin-1 Protein, CF has been validated for the following applications: Binding Activity.
target :
Netrin-1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in HEPES, NaCl with Trehalose.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
83 kDa, reducing conditions
theoretical molecular weight :
68.2 kDa
gene symbol :
Ntn1
details of functionality :
Measured by its binding ability in a functional ELISA. Immobilized recombinant rat UNC5H2 Fc Chimera at 5 ╡g/mL (100 ╡L/well) can bind Recombinant Mouse Netrin-1 with a linear range of 3-200 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse Netrin-1 Protein SDS-PAGE
accessionNumbers :
AAC52971
applications :
Binding Activity
source :
NS0-derived Recombinant Mouse Netrin-1 Protein, CF
USD :
432 USD
alt names :
netrin 1, netrin-1, Netrin1, NTN1, NTN1Lnetrin 1, mouse, homolog of
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.