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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Kallikrein 5 Protein, CF
catalog :
1108-SE-010
quantity :
10 ug
price :
523 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Smiljanic S, Messaraa C, Lafon Kolb V, Hrapovic N, Amini N, Osterlund C, et al. Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits. Int J Mol Sci. 2022;23: pubmed publisher
Roh K, Jang Y, Cho E, Park D, Kweon D, Jung E. Chlorogenic Acid Isomers Isolated from Artemisia lavandulaefolia Exhibit Anti-Rosacea Effects In Vitro. Biomedicines. 2022;10: pubmed publisher
Nargis T, Kumar K, Ghosh A, Sharma A, Rudra D, Sen D, et al. KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes. Mol Metab. 2017;6:1529-1539 pubmed publisher
Matsubara Y, Matsumoto T, Koseki J, Kaneko A, Aiba S, Yamasaki K. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22: pubmed publisher
Magnen M, Gueugnon F, Guillon A, Baranek T, Thibault V, Petit Courty A, et al. Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs. J Virol. 2017;91: pubmed publisher
Fortelny N, Butler G, Overall C, Pavlidis P. Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions. Mol Cell Proteomics. 2017;16:1038-1051 pubmed publisher
Straus M, Whittaker G. A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site. PLoS ONE. 2017;12:e0174827 pubmed publisher
Ariès M, Hernandez Pigeon H, Vaissiere C, Delga H, Caruana A, Lévêque M, et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models. Clin Cosmet Investig Dermatol. 2016;9:421-434 pubmed
Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine D, Chen J, et al. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS ONE. 2016;11:e0161465 pubmed publisher
Yamamoto Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, et al. Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation. J Biol Chem. 2014;289:20026-38 pubmed publisher
Fischer J, Koblyakova Y, Latendorf T, Wu Z, Meyer Hoffert U. Cross-linking of SPINK6 by transglutaminases protects from epidermal proteases. J Invest Dermatol. 2013;133:1170-7 pubmed publisher
Fortugno P, Bresciani A, Paolini C, Pazzagli C, El Hachem M, D Alessio M, et al. Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: implications for skin homeostasis. J Invest Dermatol. 2011;131:2223-32 pubmed publisher
Kantyka T, Fischer J, Wu Z, Declercq W, Reiss K, Schroder J, et al. Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides. 2011;32:1187-92 pubmed publisher
Meyer Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, et al. Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. J Biol Chem. 2010;285:32174-81 pubmed publisher
Sales K, Masedunskas A, Bey A, Rasmussen A, Weigert R, List K, et al. Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nat Genet. 2010;42:676-83 pubmed publisher
Morizane S, Yamasaki K, Kabigting F, Gallo R. Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid. J Invest Dermatol. 2010;130:1297-306 pubmed publisher
Sexton D, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, et al. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases. Biochem J. 2009;422:383-92 pubmed publisher
Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y, Kataoka H. Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases. FEBS J. 2008;275:1003-17 pubmed publisher
Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007;13:975-80 pubmed
product information
brand :
R&D Systems
master code :
1108-SE
SKU :
1108-SE-010
product name :
Recombinant Human Kallikrein 5 Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human Kallikrein 5 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Kallikrein 5 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Kallikrein 5
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES, NaCl and Glycerol.
conjugate :
Unconjugated
dilution :
Enzyme Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
37-42 kDa, reducing conditions
theoretical molecular weight :
27 kDa
gene symbol :
KLK5
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC (Catalog # ES011 ). The specific activity is 200 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human Kallikrein 5 Protein Enzyme Activity
accessionNumbers :
Q9Y337
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Kallikrein 5 Protein, CF
USD :
523 USD
alt names :
EC 3.4.21, EC 3.4.21.4, kallikrein 5, Kallikrein-like protein 2, kallikrein-related peptidase 5, KLK5, KLKL2, KLK-L2, KLK-L2EC 3.4.21.-, SCTE, SCTEkallikrein-5, Stratum corneum tryptic enzyme
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.