Recombinant Human HAI-2A Protein, CF | R&D Systems 1106-PI-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human HAI-2A Protein, CF

catalog :

1106-PI-010

quantity :

10 ug

price :

468 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Szabo R, Bugge T. Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy. PLoS ONE. 2018;13:e0194660 pubmed publisher
Zoratti G, Tanabe L, Varela F, Murray A, Bergum C, Colombo Ã, et al. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015;6:6776 pubmed publisher
Szabo R, Hobson J, List K, Molinolo A, Lin C, Bugge T. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem. 2008;283:29495-504 pubmed publisher

product information

brand :

R&D Systems

master code :

1106-PI

SKU :

1106-PI-010

product name :

Recombinant Human HAI-2A Protein, CF

unit size :

10 ug

seo description :

The Recombinant Human HAI-2A Protein, CF from R&D Systems is derived from NS0. The Recombinant Human HAI-2A Protein, CF has been validated for the following applications: Inhibition Activity.

target :

HAI-2A

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris, NaCl and CaCl2.

conjugate :

Unconjugated

dilution :

Inhibition Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

27 kDa and 32 kDa, reducing conditions

theoretical molecular weight :

21 kDa

gene symbol :

SPINT2

details of functionality :

Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog # ES002 ). The IC50 value is 4.6 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

O43291

applications :

Inhibition Activity

source :

NS0-derived Recombinant Human HAI-2A Protein, CF

USD :

468 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage