Recombinant Human IL-20 Protein | R&D Systems 1102-IL-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-20 Protein

catalog :

1102-IL-025

quantity :

25 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Dayton J, Yuan Y, Pacumio L, Dorflinger B, Yoo S, Olson M, et al. Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation. Front Cell Neurosci. 2021;15:683687 pubmed publisher
Kong L, Jiang D, He C, Xia J, Wei H, Zhou L, et al. TgROP18 targets IL20RB for host-defense-related-STAT3 activation during Toxoplasma gondii infection. Parasit Vectors. 2020;13:400 pubmed publisher
Moniruzzaman M, Wang R, Jeet V, McGuckin M, Hasnain S. Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway. Int J Mol Sci. 2019;20: pubmed publisher
Gough P, Ganesan S, Datta S. IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function. J Immunol. 2017;198:4373-4382 pubmed publisher
Tsaousi A, Witte E, Witte K, Röwert Huber H, Volk H, Sterry W, et al. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators Inflamm. 2016;2016:4097574 pubmed
Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, et al. Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. Oncogene. 2017;36:1276-1286 pubmed publisher
Heinemann A, He Y, Zimina E, Boerries M, Busch H, Chmel N, et al. Induction of phenotype modifying cytokines by FERMT1 mutations. Hum Mutat. 2011;32:397-406 pubmed publisher
Wolk K, Witte E, Warszawska K, Schulze Tanzil G, Witte K, Philipp S, et al. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur J Immunol. 2009;39:3570-81 pubmed publisher
Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, et al. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur J Immunol. 2009;39:2779-88 pubmed publisher
Wolk K, Witte K, Witte E, Proesch S, Schulze Tanzil G, Nasilowska K, et al. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J Leukoc Biol. 2008;83:1181-93 pubmed publisher
Sa S, Valdez P, Wu J, Jung K, Zhong F, Hall L, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol. 2007;178:2229-40 pubmed

product information

brand :

R&D Systems

master code :

1102-IL

SKU :

1102-IL-025

product name :

Recombinant Human IL-20 Protein

unit size :

25 ug

seo description :

The Recombinant Human IL-20 Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-20 Protein has been validated for the following applications: Bioactivity.

target :

IL-20

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

17.6 kDa

gene symbol :

IL20

details of functionality :

Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human IL-20 R alpha and human IL-20 R▀. The ED50 for this effect is 0.05-0.3 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAF36679

applications :

Bioactivity

source :

E. coli-derived Recombinant Human IL-20 Protein

USD :

400 USD

alt names :

Cytokine Zcyto10, IL10D, IL20, IL-20ZCYTO10four alpha helix cytokine, interleukin 20, interleukin-20, MGC96907

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage