Recombinant Human IL-36 beta/IL-1F8 Protein | R&D Systems 1099-IL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-36 beta/IL-1F8 Protein

catalog :

1099-IL

quantity :

25 ug

price :

329 USD

citations: 4

Reference
Lacy S, Wu C, Ambrosi D, Hsieh C, Bose S, Miller R, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1Î± and IL-1Î². MAbs. 2015;7:605-19 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Carrier Y, Ma H, Ramon H, Napierata L, Small C, O Toole M, et al. Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis. J Invest Dermatol. 2011;131:2428-37 pubmed publisher
Magne D, Palmer G, Barton J, Mezin F, Talabot Ayer D, Bas S, et al. The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Res Ther. 2006;8:R80 pubmed

product information

brand :

R&D Systems

master code :

1099-IL

SKU :

1099-IL-025

product name :

Recombinant Human IL-36 beta/IL-1F8 Protein

description :

The Recombinant Human IL-36 beta/IL-1F8 Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-36 beta/IL-1F8 Protein has been validated for the following applications: Binding Activity.

target :

IL-36 beta/IL-1F8

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

17.7 kDa

gene symbol :

IL36B

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL-36 beta at 1 µg/mL (100 µL/well) can bind recombinant human IL-1 Rrp2 Fc Chimera (Catalog # 872-RP) with a linear range of 0.15-5 µg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

1099-IL

accessionNumbers :

Q3MIH0

applications :

Binding Activity

source :

E. coli -derived human IL-36 beta/IL-1F8 protein Met1-Glu157

extended description :

A New rh IL-36b is Now Available! The new truncated protein is 40-fold more active!

2020 USD :

329

2021 USD :

329 USD

product details :

A New rh IL-36b is Now Available! The new truncated protein is 40-fold more active!

alt names :

family of interleukin 1-eta, FIL1, FIL1 eta, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1 eta, IL1-ETA, IL1F8, IL-1F8, IL1F8 (Canonical product IL-1F8a), IL-1F8 (FIL1-eta), IL1H2, IL-1H2, IL36 beta, IL36B, interleukin 1 family, member 8 (eta), interleukin 1, eta, Interleukin 36, Beta, Interleukin-1 eta, interleukin-1 family member 8, Interleukin-1 homolog 2, Interleukin-1 Superfamily e, Interleukin-36 Beta

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.