Recombinant Human Endoglin/CD105 Protein | R&D Systems 1097-EN product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Endoglin/CD105 Protein

catalog :

1097-EN

quantity :

25 ug

price :

339 USD

citations: 7

Reference
Gallardo Vara E, Gamella Pozuelo L, Pérez Roque L, Bartha J, García Palmero I, Casal J, et al. Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. Cells. 2020;9: pubmed publisher
Gallardo Vara E, Ruiz Llorente L, Casado Vela J, Ruiz Rodríguez M, Lopez Andres N, Pattnaik A, et al. Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Cells. 2019;8: pubmed publisher
Walker D, Lue L, Beach T, Tooyama I. Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin. Cells. 2019;8: pubmed publisher
Ruiz Remolina L, Ollauri Ibáñez C, Pérez Roque L, Núñez Gómez E, Perez Barriocanal F, Lopez Novoa J, et al. Circulating soluble endoglin modifies the inflammatory response in mice. PLoS ONE. 2017;12:e0188204 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Rossi E, Sanz Rodriguez F, Eleno N, Düwell A, Blanco F, Langa C, et al. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood. 2013;121:403-15 pubmed publisher
Hawinkels L, Kuiper P, Wiercinska E, Verspaget H, Liu Z, Pardali E, et al. Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res. 2010;70:4141-50 pubmed publisher

product information

brand :

R&D Systems

master code :

1097-EN

SKU :

1097-EN-025

product name :

Recombinant Human Endoglin/CD105 Protein

description :

The Recombinant Human Endoglin/CD105 Protein from R&D Systems is derived from NS0. The Recombinant Human Endoglin/CD105 Protein has been validated for the following applications: Bioactivity.

target :

Endoglin/CD105

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

75-85 kDa, reducing conditions

theoretical molecular weight :

61 kDa

gene symbol :

ENG

details of functionality :

Measured by its ability to inhibit BMP-10-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.06-0.36 µg/mL in the presence of 100 ng/mL of Recombinant Human BMP-10 (Catalog # 2926-BP ).

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1097-EN

accessionNumbers :

Q5T9C0

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human Endoglin/CD105 protein Glu26-Gly586

extended description :

A New rh Endoglin is Available! It has ~100 fold better TGFbRI binding activity and has a Fc tag!

2020 USD :

339

2021 USD :

339 USD

product details :

A New rh Endoglin is Available! It has ~100 fold better TGFbRI binding activity and has a Fc tag!

alt names :

CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, ENG, HHT1FLJ41744, ORW, ORW1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.