product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Endoglin/CD105 Protein
catalog :
1097-EN-025
quantity :
25 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Haarmann A, Zimmermann L, Bieber M, Silwedel C, Stoll G, Schuhmann M. Regulation and Release of Vasoactive Endoglin by Brain Endothelium in Response to Hypoxia/Reoxygenation in Stroke. Int J Mol Sci. 2022;23: pubmed publisher
Park E, Kim S, Yao D, Savarraj J, Choi H, Chen P, et al. Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction. Int J Mol Sci. 2022;23: pubmed publisher
Pérez Roque L, Núñez Gómez E, Rodriguez Barbero A, Bernabeu C, Lopez Novoa J, Pericacho M. Pregnancy-Induced High Plasma Levels of Soluble Endoglin in Mice Lead to Preeclampsia Symptoms and Placental Abnormalities. Int J Mol Sci. 2020;22: pubmed publisher
Gallardo Vara E, Gamella Pozuelo L, Pérez Roque L, Bartha J, García Palmero I, Casal J, et al. Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. Cells. 2020;9: pubmed publisher
Pous L, Deshpande S, Nath S, Mezey S, Malik S, Schildge S, et al. Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. Nat Commun. 2020;11:630 pubmed publisher
Gallardo Vara E, Ruiz Llorente L, Casado Vela J, Ruiz Rodríguez M, Lopez Andres N, Pattnaik A, et al. Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Cells. 2019;8: pubmed publisher
Walker D, Lue L, Beach T, Tooyama I. Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin. Cells. 2019;8: pubmed publisher
Ruiz Remolina L, Ollauri Ibáñez C, Pérez Roque L, Núñez Gómez E, Perez Barriocanal F, Lopez Novoa J, et al. Circulating soluble endoglin modifies the inflammatory response in mice. PLoS ONE. 2017;12:e0188204 pubmed publisher
Olsen O, Wader K, Misund K, Våtsveen T, Rø T, Mylin A, et al. Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J. 2014;4:e196 pubmed publisher
Rossi E, Sanz Rodriguez F, Eleno N, Düwell A, Blanco F, Langa C, et al. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood. 2013;121:403-15 pubmed publisher
Hawinkels L, Kuiper P, Wiercinska E, Verspaget H, Liu Z, Pardali E, et al. Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res. 2010;70:4141-50 pubmed publisher
product information
brand :
R&D Systems
master code :
1097-EN
SKU :
1097-EN-025
product name :
Recombinant Human Endoglin/CD105 Protein
unit size :
25 ug
seo description :
The Recombinant Human Endoglin/CD105 Protein from R&D Systems is derived from NS0. The Recombinant Human Endoglin/CD105 Protein has been validated for the following applications: Bioactivity.
target :
Endoglin/CD105
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
75-85 kDa, reducing conditions
theoretical molecular weight :
61 kDa
gene symbol :
ENG
details of functionality :
Measured by its ability to inhibit BMP-10-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.06-0.36 ╡g/mL in the presence of 100 ng/mL of Recombinant Human BMP-10 (Catalog # 2926-BP ).
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q5T9C0
applications :
Bioactivity
source :
NS0-derived Recombinant Human Endoglin/CD105 Protein
USD :
432 USD
alt names :
CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, ENG, HHT1FLJ41744, ORW, ORW1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.