Recombinant Human IL-22BP Fc Chimera Protein, CF | R&D Systems 1087-BP-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-22BP Fc Chimera Protein, CF

catalog :

1087-BP-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Wang Y, Mumm J, Herbst R, Kolbeck R, Wang Y. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression. J Immunol. 2017;199:3316-3325 pubmed publisher
Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, et al. Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes. J Neuroinflammation. 2015;12:119 pubmed publisher
Witte K, Gruetz G, Volk H, Looman A, Asadullah K, Sterry W, et al. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun. 2009;10:702-14 pubmed publisher
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity. 2004;21:241-54 pubmed
Donnelly R, Sheikh F, Kotenko S, Dickensheets H. The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J Leukoc Biol. 2004;76:314-21 pubmed

product information

brand :

R&D Systems

master code :

1087-BP

SKU :

1087-BP-025

product name :

Recombinant Human IL-22BP Fc Chimera Protein, CF

unit size :

25 ug

seo description :

The Recombinant Human IL-22BP Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-22BP Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-22BP

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

75-80 kDa, reducing conditions

theoretical molecular weight :

51.3 kDa (monomer)

gene symbol :

IL22RA2

details of functionality :

Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 4-20 ng/mL in the presence of 1 ng/mL of Recombinant Human IL-22 (Catalog # 782-IL ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_851826

applications :

Bioactivity

source :

NS0-derived Recombinant Human IL-22BP Fc Chimera Protein, CF

USD :

432 USD

alt names :

class II cytokine receptor, CRF2-10, CRF2-S1IL22BP, CRF2-X, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, Cytokine receptor family type 2, soluble 1, IL-22 RA2, IL-22 receptor subunit alpha-2, IL22BP, IL-22BPCRF2X, IL22RA2, IL-22RA2, IL-22R-alpha-2, interleukin 22 receptor, alpha 2, interleukin 22-binding protein, interleukin-22 receptor subunit alpha-2, Interleukin-22-binding protein, MGC150509, MGC150510, zcytoR16

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage