Recombinant Mouse Artemin Protein | R&D Systems 1085-AR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Artemin Protein

catalog :

1085-AR-025

quantity :

25 ug

price :

425 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Yang C, Wei C, Alam S, Chen X, McKemy D. The neurotrophic factor artemin and its receptor GFRα3 mediate migraine-like pain via the ion channel TRPM8. bioRxiv. 2024;: pubmed publisher
Yang C, Yamaki S, Jung T, Kim B, Huyhn R, McKemy D. Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 and GFRα3. bioRxiv. 2023;: pubmed publisher
Jeong S, Zhang H, Yamaki S, Yang C, McKemy D, Lieber M, et al. Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization. Nucleic Acids Res. 2022;50:11738-11754 pubmed publisher
Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, et al. Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression. Cell. 2018;173:634-648.e12 pubmed publisher
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, et al. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons. Proc Natl Acad Sci U S A. 2017;114:E2486-E2493 pubmed publisher
Lippoldt E, Ongun S, Kusaka G, McKemy D. Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFR?3. Proc Natl Acad Sci U S A. 2016;113:4506-11 pubmed publisher
Ikeda Miyagawa Y, Kobayashi K, Yamanaka H, Okubo M, Wang S, Dai Y, et al. Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons. Mol Pain. 2015;11:8 pubmed publisher
Bohórquez D, Samsa L, Roholt A, Medicetty S, Chandra R, Liddle R. An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. PLoS ONE. 2014;9:e89881 pubmed publisher
Li J, Klein C, Liang C, Rauch R, Kawamura K, Hsueh A. Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. FEBS Lett. 2009;583:2479-85 pubmed publisher
Malin S, Molliver D, Koerber H, Cornuet P, Frye R, Albers K, et al. Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J Neurosci. 2006;26:8588-99 pubmed

product information

brand :

R&D Systems

master code :

1085-AR

SKU :

1085-AR-025

product name :

Recombinant Mouse Artemin Protein

unit size :

25 ug

seo description :

The Recombinant Mouse Artemin Protein from R&D Systems is derived from E. coli. The Recombinant Mouse Artemin Protein has been validated for the following applications: Bioactivity, Binding Activity.

target :

Artemin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity, Binding Activity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

theoretical molecular weight :

12 kDa (monomer)

gene symbol :

Artn

details of functionality :

Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is 2-8 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse GFR alpha -3/GDNF R alpha -3 Fc Chimera (Catalog # 2645-FR ) at 1 ╡g/mL (100 ╡L/well) can bind Recombinant Mouse Artemin with an apparent KD 1 nM.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9Z0L2.1

applications :

Bioactivity, Binding Activity

source :

E. coli-derived Recombinant Mouse Artemin Protein

USD :

425 USD

alt names :

artemin, ARTN, ENOVIN, EVN, EVNneurotrophic factor, NBN, Neublastin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage