Recombinant Human Cathepsin V Protein, CF | R&D Systems 1080-CY product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Cathepsin V Protein, CF

catalog :

1080-CY

quantity :

10 ug

price :

339 USD

citations: 7

Reference
Lindstrom E, Rizoska B, Henderson I, Terelius Y, Jerling M, Edenius C, et al. Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711. J Transl Med. 2018;16:125 pubmed publisher
Yi W, Su M, Shi Y, Jiang S, Xu S, Lei T. Degraded melanocores are incompetent to protect epidermal keratinocytes against UV damage. Cell Cycle. 2018;17:844-857 pubmed publisher
Schaal J, Tran D, Subramanian A, Patel R, Laragione T, Roberts K, et al. Suppression and resolution of autoimmune arthritis by rhesus ?-defensin-1, an immunomodulatory macrocyclic peptide. PLoS ONE. 2017;12:e0187868 pubmed publisher
Jiang H, Cheng X, Shi G, Hu L, Inoue A, Yamamura Y, et al. Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nat Commun. 2014;5:3838 pubmed publisher
Zou F, Schäfer N, Palesch D, Brücken R, Beck A, Sienczyk M, et al. Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients. PLoS ONE. 2011;6:e22815 pubmed publisher
Ma D, Yao J, Kuo M, See L, Lin K, Chen S, et al. Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane. Invest Ophthalmol Vis Sci. 2007;48:644-51 pubmed
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed

product information

brand :

R&D Systems

master code :

1080-CY

SKU :

1080-CY-010

product name :

Recombinant Human Cathepsin V Protein, CF

description :

The Recombinant Human Cathepsin V Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin V Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Cathepsin V

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Sodium Acetate and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

40 kDa, reducing conditions

theoretical molecular weight :

37 kDa

gene symbol :

CTSV

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC (Catalog # ES008 ). The specific activity is 400 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1080-CY

accessionNumbers :

O60911

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human Cathepsin V protein Val18-Val334, with a C-terminal 10-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

cathepsin L2, Cathepsin U, Cathepsin V, CATL2, CTSL2, CTSUcathepsin L2, preproprotein, CTSVMGC125957, EC 3.4.22, EC 3.4.22.43

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.