product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Cathepsin V Protein, CF
catalog :
1080-CY-010
quantity :
10 ug
price :
432 USD
more info or order :
citations: 7
Reference
Lindstrom E, Rizoska B, Henderson I, Terelius Y, Jerling M, Edenius C, et al. Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711. J Transl Med. 2018;16:125 pubmed publisher
Yi W, Su M, Shi Y, Jiang S, Xu S, Lei T. Degraded melanocores are incompetent to protect epidermal keratinocytes against UV damage. Cell Cycle. 2018;17:844-857 pubmed publisher
Schaal J, Tran D, Subramanian A, Patel R, Laragione T, Roberts K, et al. Suppression and resolution of autoimmune arthritis by rhesus ?-defensin-1, an immunomodulatory macrocyclic peptide. PLoS ONE. 2017;12:e0187868 pubmed publisher
Jiang H, Cheng X, Shi G, Hu L, Inoue A, Yamamura Y, et al. Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nat Commun. 2014;5:3838 pubmed publisher
Zou F, Schäfer N, Palesch D, Brücken R, Beck A, Sienczyk M, et al. Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients. PLoS ONE. 2011;6:e22815 pubmed publisher
Ma D, Yao J, Kuo M, See L, Lin K, Chen S, et al. Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane. Invest Ophthalmol Vis Sci. 2007;48:644-51 pubmed
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed
product information
brand :
R&D Systems
master code :
1080-CY
SKU :
1080-CY-010
product name :
Recombinant Human Cathepsin V Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human Cathepsin V Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin V Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Cathepsin V
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in Sodium Acetate and NaCl.
conjugate :
Unconjugated
dilution :
Enzyme Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
40 kDa, reducing conditions
theoretical molecular weight :
37 kDa
gene symbol :
CTSV
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC (Catalog # ES008 ). The specific activity is 400 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O60911
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Cathepsin V Protein, CF
USD :
432 USD
alt names :
cathepsin L2, Cathepsin U, Cathepsin V, CATL2, CTSL2, CTSUcathepsin L2, preproprotein, CTSVMGC125957, EC 3.4.22, EC 3.4.22.43
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.