Recombinant Human Siglec-5 Fc Chimera Protein, CF | R&D Systems 1072-SL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Siglec-5 Fc Chimera Protein, CF

catalog :

1072-SL

quantity :

50 ug

price :

359 USD

citations: 6

Reference
Terävä J, Tiainen L, Lamminmaki U, Kellokumpu Lehtinen P, Pettersson K, Gidwani K. Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma. PLoS ONE. 2019;14:e0219480 pubmed publisher
Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini E, et al. Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity. Sci Rep. 2016;6:37953 pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, et al. Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. PLoS ONE. 2011;6:e24559 pubmed publisher
Nordstrom T, Movert E, Olin A, Ali S, Nizet V, Varki A, et al. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. J Biol Chem. 2011;286:33981-91 pubmed publisher
Zhuravleva M, Trandem K, Sun P. Structural implications of Siglec-5-mediated sialoglycan recognition. J Mol Biol. 2008;375:437-47 pubmed

product information

brand :

R&D Systems

master code :

1072-SL

SKU :

1072-SL-050

product name :

Recombinant Human Siglec-5 Fc Chimera Protein, CF

description :

The Recombinant Human Siglec-5 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Siglec-5 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Siglec-5/CD170

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

73 kDa (monomer)

gene symbol :

SIGLEC5

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED50 for this effect is 1-4 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

1072-SL

accessionNumbers :

O15389

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human Siglec-5/CD170 protein Human Siglec-5 (Glu17-Thr434) Accession # O15389 IEGRID Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

359

2021 USD :

359 USD

alt names :

CD170, CD170 antigen, CD33 antigen-like 2, CD33L2, CD33L2OB binding protein-2, OBBP2, OB-BP2OB-binding protein 2, OBBP2sialic acid-binding Ig-like lectin 5, Obesity-binding protein 2, sialic acid binding Ig-like lectin 5, sialic acid-binding immunoglobulin-like lectin 5, Siglec5, SIGLEC-5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.