product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Siglec-5 Fc Chimera Protein, CF
catalog :
1072-SL-050
quantity :
50 ug
price :
456 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Benucci B, Spinello Z, Calvaresi V, Viviani V, Perrotta A, Faleri A, et al. Neisserial adhesin A (NadA) binds human Siglec-5 and Siglec-14 with high affinity and promotes bacterial adhesion/invasion. MBio. 2024;15:e0110724 pubmed publisher
Lozano Rodr xed guez R, Avenda xf1 o Ort xed z J, Montalb xe1 n Hern xe1 ndez K, Ruiz Rodr xed guez J, Ferrer R, Mart xed n Quir xf3 s A, et al. The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis. EBioMedicine. 2023;97:104841 pubmed publisher
Chan C, Lustig M, Jansen J, Garcia Villagrasa L, Raymakers L, Daamen L, et al. Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9. Cancers (Basel). 2023;15: pubmed publisher
Michaud E, Waeckel L, Gayet R, Goguyer Deschaumes R, Chanut B, Jospin F, et al. Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in inflammatory bowel diseases. EMBO Mol Med. 2022;14:e15386 pubmed publisher
Terävä J, Tiainen L, Lamminmaki U, Kellokumpu Lehtinen P, Pettersson K, Gidwani K. Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma. PLoS ONE. 2019;14:e0219480 pubmed publisher
Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini E, et al. Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity. Sci Rep. 2016;6:37953 pubmed publisher
Chen G, Brown N, Wu W, Khedri Z, Yu H, Chen X, et al. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. elife. 2014;3:e04066 pubmed publisher
Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, et al. Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. PLoS ONE. 2011;6:e24559 pubmed publisher
Nordstrom T, Movert E, Olin A, Ali S, Nizet V, Varki A, et al. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. J Biol Chem. 2011;286:33981-91 pubmed publisher
Zhuravleva M, Trandem K, Sun P. Structural implications of Siglec-5-mediated sialoglycan recognition. J Mol Biol. 2008;375:437-47 pubmed
product information
brand :
R&D Systems
master code :
1072-SL
SKU :
1072-SL-050
product name :
Recombinant Human Siglec-5 Fc Chimera Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human Siglec-5 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Siglec-5 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Siglec-5/CD170
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
100-110 kDa, reducing conditions
theoretical molecular weight :
73 kDa (monomer)
gene symbol :
SIGLEC5
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. Kelm, S. et al . (1994) Current Biology 4 :965. The ED50 for this effect is 1-4á╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O15389
applications :
Bioactivity
source :
NS0-derived Recombinant Human Siglec-5 Fc Chimera Protein, CF
USD :
456 USD
alt names :
CD170, CD170 antigen, CD33 antigen-like 2, CD33L2, CD33L2OB binding protein-2, OBBP2, OB-BP2OB-binding protein 2, OBBP2sialic acid-binding Ig-like lectin 5, Obesity-binding protein 2, sialic acid binding Ig-like lectin 5, sialic acid-binding immunoglobulin-like lectin 5, Siglec5, SIGLEC-5
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.