Recombinant Human Cathepsin C/DPPI Protein, CF | R&D Systems 1071-CY product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Cathepsin C/DPPI Protein, CF

catalog :

1071-CY

quantity :

10 ug

price :

339 USD

citations: 5

Reference
Schaal J, Tran D, Subramanian A, Patel R, Laragione T, Roberts K, et al. Suppression and resolution of autoimmune arthritis by rhesus ?-defensin-1, an immunomodulatory macrocyclic peptide. PLoS ONE. 2017;12:e0187868 pubmed publisher
Hamilton G, Colbert J, Schuettelkopf A, Watts C. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis. EMBO J. 2008;27:499-508 pubmed publisher
Burster T, Marin Esteban V, Boehm B, Dunn S, Rotzschke O, Falk K, et al. Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions. Biochem Pharmacol. 2007;74:1514-23 pubmed
Methot N, Rubin J, Guay D, Beaulieu C, Ethier D, Reddy T, et al. Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007;282:20836-46 pubmed
Falgueyret J, Black W, Cromlish W, Desmarais S, Lamontagne S, Mellon C, et al. An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells. Anal Biochem. 2004;335:218-27 pubmed

product information

brand :

R&D Systems

master code :

1071-CY

SKU :

1071-CY-010

product name :

Recombinant Human Cathepsin C/DPPI Protein, CF

description :

The Recombinant Human Cathepsin C/DPPI Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin C/DPPI Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Cathepsin C/DPPI

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

60 kDa, reducing conditions

theoretical molecular weight :

51 kDa

gene symbol :

CTSC

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is 200 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1071-CY

accessionNumbers :

P53634

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human Cathepsin C/DPPI protein Asp25-Leu463, with a C-terminal 10-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

cathepsin CEC 3.4.14.1, Cathepsin J, CPPIHMS, CTSC, dipeptidyl peptidase 1, Dipeptidyl peptidase I, Dipeptidyl transferase, dipeptidyl-peptidase I, DPP1, DPPI, DPP-I, JP, JPD, PALS, PLS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.