product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Cathepsin C/DPPI Protein, CF
catalog :
1071-CY-010
quantity :
10 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Yuan L, Qin Q, Yao Y, Chen L, Liu H, Du X, et al. Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma. JCI Insight. 2024;9: pubmed publisher
Sutton V, Watt S, Akhlaghi H, Cipolla D, Chen K, LaSala D, et al. Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells. Front Pharmacol. 2024;15:1396710 pubmed publisher
Kim S, Lee K, Choi H, Kim E, Kang S, Han M, et al. Hederacolchiside A1 Suppresses Autophagy by Inhibiting Cathepsin C and Reduces the Growth of Colon Cancer. Cancers (Basel). 2023;15: pubmed publisher
Cheung P, Schaffert S, Chang S, Dvorak M, Donato M, Macaubas C, et al. Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation. Nat Immunol. 2021;22:711-722 pubmed publisher
Kim S, Lee S, Kim N, Joo M, Lee K, Lee M, et al. Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C. Am J Cancer Res. 2021;11:1304-1320 pubmed
Schaal J, Tran D, Subramanian A, Patel R, Laragione T, Roberts K, et al. Suppression and resolution of autoimmune arthritis by rhesus ?-defensin-1, an immunomodulatory macrocyclic peptide. PLoS ONE. 2017;12:e0187868 pubmed publisher
Hamilton G, Colbert J, Schuettelkopf A, Watts C. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis. EMBO J. 2008;27:499-508 pubmed publisher
Burster T, Marin Esteban V, Boehm B, Dunn S, Rotzschke O, Falk K, et al. Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions. Biochem Pharmacol. 2007;74:1514-23 pubmed
Methot N, Rubin J, Guay D, Beaulieu C, Ethier D, Reddy T, et al. Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007;282:20836-46 pubmed
Falgueyret J, Black W, Cromlish W, Desmarais S, Lamontagne S, Mellon C, et al. An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells. Anal Biochem. 2004;335:218-27 pubmed
product information
brand :
R&D Systems
master code :
1071-CY
SKU :
1071-CY-010
product name :
Recombinant Human Cathepsin C/DPPI Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human Cathepsin C/DPPI Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin C/DPPI Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Cathepsin C/DPPI
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES and NaCl.
conjugate :
Unconjugated
dilution :
Enzyme Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
60 kDa, reducing conditions
theoretical molecular weight :
51 kDa
gene symbol :
CTSC
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is 200 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P53634
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Cathepsin C/DPPI Protein, CF
USD :
432 USD
alt names :
cathepsin CEC 3.4.14.1, Cathepsin J, CPPIHMS, CTSC, dipeptidyl peptidase 1, Dipeptidyl peptidase I, Dipeptidyl transferase, dipeptidyl-peptidase I, DPP1, DPPI, DPP-I, JP, JPD, PALS, PLS
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.