Recombinant Human Activin AB Protein, CF | R&D Systems 1066-AB-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin AB Protein, CF

catalog :

1066-AB-010/CF

quantity :

10 ug (also 25 ug)

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Goh B, Singhal V, Herrera A, Tomlinson R, Kim S, Faugere M, et al. Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. J Biol Chem. 2017;292:13809-13822 pubmed publisher
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher
Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El Sayed K, et al. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-Î². PLoS ONE. 2015;10:e0118097 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed

product information

master code :

1066-AB/CF

SKU :

1066-AB-010/CF

product name :

Recombinant Human Activin AB Protein, CF

unit size :

10 ug (also 25 ug)

description :

The Recombinant Human Activin AB Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Activin AB Protein, CF has been validated for the following applications: Bioactivity.

target :

Activin AB

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with Trehalose.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

14 kDa, reducing conditions

theoretical molecular weight :

12.8 kDa (▀A subunit) and 13 kDa (▀B subunit)

details of functionality :

Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. etáal . (1991) Method Enzymol. 198 :340. The ED50 for this effect is 0.2-1.2 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_002183 (▀A) NP_002184 (▀B)

applications :

Bioactivity

source long :

Chinese Hamster Ovary cell line, CHO-derived human Activin AB protein Human Activin ▀A (Gly311 - Ser426) Accession # NP_002183.1 Human Activin ▀B (Gly293 - Ala407) Accession # NP_002184.2 N-terminus C-terminus

source short :

CHO

USD :

456 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage