product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant SARS-CoV-2 Spike His Protein, CF
catalog :
10549-CV-100
quantity :
100 ug (also 1 mg)
price :
599 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
McGee J, Kirsch J, Kenney D, Cerbo F, Chavez E, Shih T, et al. Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency. Nat Biotechnol. 2024;: pubmed publisher
Piepenbrink M, Khalil A, Chang A, Mostafa A, Basu M, Sarkar S, et al. Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants. bioRxiv. 2024;: pubmed publisher
Kiszel P, S xed k P, Mikl xf3 s J, Kajd xe1 csi E, Sinkovits G, Cervenak L, et al. Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history. Sci Rep. 2023;13:13166 pubmed publisher
Sinkovits G, Schnur J, Hurler L, Kiszel P, Proh xe1 szka Z, S xed k P, et al. Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children. Sci Rep. 2022;12:19759 pubmed publisher
Godellas N, Cymes G, Grosman C. An experimental test of the nicotinic hypothesis of COVID-19. Proc Natl Acad Sci U S A. 2022;119:e2204242119 pubmed publisher
Kiyan Y, Schultalbers A, Chernobrivaia E, Tkachuk S, Rong S, Shushakova N, et al. Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate. Sci Rep. 2022;12:16878 pubmed publisher
Lea C, Simeonsson K, Kipp A, McNeill C, Wilcox L, Irish W, et al. Waning of SARS-CoV-2 Seropositivity among Healthy Young Adults over Seven Months. Vaccines (Basel). 2022;10: pubmed publisher
Bhargavan B, Kanmogne G. SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy Pathogenesis. Int J Mol Sci. 2022;23: pubmed publisher
Piepenbrink M, Park J, Deshpande A, Loos A, Ye C, Basu M, et al. Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody. PLoS Pathog. 2022;18:e1010691 pubmed publisher
Geanes E, LeMaster C, Fraley E, Khanal S, McLennan R, Grundberg E, et al. Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination. Sci Rep. 2022;12:6496 pubmed publisher
Chang J, Chiou J, Hung C, Liu M, Chang H, Hong S, et al. Humoral Immunogenicity and Reactogenicity of the Standard ChAdOx1 nCoV-19 Vaccination in Taiwan. Vaccines (Basel). 2022;10: pubmed publisher
Robles J, Zamora M, Adan Castro E, Siqueiros Marquez L, Martinez de la Escalera G, Clapp C. The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling. J Biol Chem. 2022;298:101695 pubmed publisher
Jover E, Matilla L, Garaikoetxea M, Fernández Celis A, Muntendam P, Jaisser F, et al. Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein. Biomedicines. 2021;9: pubmed publisher
product information
brand :
R&D Systems
master code :
10549-CV
SKU :
10549-CV-100
product name :
Recombinant SARS-CoV-2 Spike His Protein, CF
unit size :
100 ug (also 1 mg)
seo description :
The Recombinant SARS-CoV-2 Spike His Protein, CF from R&D Systems is derived from HEK293. The Recombinant SARS-CoV-2 Spike His Protein, CF has been validated for the following applications: Bioactivity.
target :
Spike
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
SARS-CoV-2
observed molecular weight :
144-175 kDa, under reducing conditions
theoretical molecular weight :
134 kDa
details of functionality :
Measured by its binding ability in a functional ELISA with Recombinant Human ACE-2 His-tag (Catalog # 933-ZN ).
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Graph showing SARS-CoV-2 Spike protein binding to ACE-2
accessionNumbers :
YP_009724390.1
applications :
Bioactivity
source :
HEK293-derived Recombinant SARS-CoV-2 Spike His Protein, CF
extended description :
Ectodomain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage
USD :
599 USD
product details :
Ectodomain, Stabilized Prefusion Conformation, Resistant to Furin Cleavage
alt names :
2019-nCoV S Protein, 2019-nCoV Spike, COVID-19 Spike, E2, Human coronavirus spike glycoprotein, Peplomer protein, S glycoprotein, S Protein, SARS-CoV-2, SARS-COV-2 S protein, SARS-COV-2 Spike glycoprotein, SARSCOV2 Spike protein, Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein, Spike glycoprotein, surface glycoprotein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.