This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human OX40 Ligand/TNFSF4 Protein, CF
catalog :
1054-OX
quantity :
10 ug
price :
339 USD
citations: 6
Reference
Thampy L, Remy K, Walton A, Hong Z, Liu K, Liu R, et al. Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration. PLoS ONE. 2018;13:e0199497 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Tanabe A, Nakano K, Nakakido M, Nagatoishi S, Tanaka Y, Tsumoto K, et al. Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery. Biochem Biophys Res Commun. 2018;496:614-620 pubmed publisher
Lobito A, Ramani S, Tom I, Bazan J, Luis E, Fairbrother W, et al. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. J Biol Chem. 2011;286:18969-81 pubmed publisher
Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, et al. Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol. 2008;20:1321-9 pubmed publisher
Willett B, McMonagle E, Bonci F, Pistello M, Hosie M. Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus. J Virol. 2006;80:7744-7 pubmed
product information
brand :
R&D Systems
master code :
1054-OX
SKU :
1054-OX-010
product name :
Recombinant Human OX40 Ligand/TNFSF4 Protein, CF
description :
The Recombinant Human OX40 Ligand/TNFSF4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human OX40 Ligand/TNFSF4 Protein, CF has been validated for the following applications: Bioactivity, Binding Activity.
target :
OX40 Ligand/TNFSF4
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
28-34 kDa, reducing conditions
theoretical molecular weight :
18 kDa
gene symbol :
TNFSF4
details of functionality :
Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with human OX40/TNFRSF4. Muller, N. et al . (2008) FEBS J. 275 :2296. The ED50 for this effect is typically 1-5 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human OX40/TNFRSF4 Fc Chimera (Catalog # 3388-OX ) is immobilized at 10 ng/mL, the concentration of Recombinant Human OX40 Ligand/TNFSF4 that produces 50% optimal binding response is found to be approximately 0.5-3 ng/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
1054-OX
accessionNumbers :
Q6FGS4
applications :
Bioactivity, Binding Activity
source :
Mouse myeloma cell line, NS0-derived human OX40 Ligand/TNFSF4 protein MHHHHHHHHHH GGGSGGGSGGGS IEGR Human OX40 Ligand (Gln51-Leu183) Accession # Q6FGS4 N-terminus C-terminus
2020 USD :
339
2021 USD :
339 USD
alt names :
CD134 ligand, CD134L, CD252, CD252 antigen, Glycoprotein Gp34, gp34, OX40 antigen ligand, OX40 ligand, OX40L, OX-40L, OX4OL, TAX transcriptionally-activated glycoprotein 1, tax-transcriptionally activated glycoprotein 1 (34kD), tax-transcriptionally activated glycoprotein 1, 34kD, TNFSF4, tumor necrosis factor (ligand) superfamily, member 4, tumor necrosis factor ligand superfamily member 4, TXGP1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.