Recombinant Human OX40 Ligand/TNFSF4 Protein, CF | R&D Systems 1054-OX-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human OX40 Ligand/TNFSF4 Protein, CF

catalog :

1054-OX-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Naoi Y, Morinaga T, Nagasaki J, Ariyasu R, Ueda Y, Yamashita K, et al. CD106 in Tumor-Specific Exhausted CD8+ T Cells Mediates Immunosuppression by Inhibiting TCR Signaling. Cancer Res. 2024;84:2109-2122 pubmed publisher
Karpf L, Trichot C, Faucheux L, Legbre I, Grandclaudon M, Lahoute C, et al. A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells. Cell Discov. 2022;8:1 pubmed publisher
Thampy L, Remy K, Walton A, Hong Z, Liu K, Liu R, et al. Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration. PLoS ONE. 2018;13:e0199497 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Tanabe A, Nakano K, Nakakido M, Nagatoishi S, Tanaka Y, Tsumoto K, et al. Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery. Biochem Biophys Res Commun. 2018;496:614-620 pubmed publisher
Lobito A, Ramani S, Tom I, Bazan J, Luis E, Fairbrother W, et al. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. J Biol Chem. 2011;286:18969-81 pubmed publisher
Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, et al. Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol. 2008;20:1321-9 pubmed publisher
Willett B, McMonagle E, Bonci F, Pistello M, Hosie M. Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus. J Virol. 2006;80:7744-7 pubmed

product information

brand :

R&D Systems

master code :

1054-OX

SKU :

1054-OX-025

product name :

Recombinant Human OX40 Ligand/TNFSF4 Protein, CF

unit size :

25 ug

seo description :

The Recombinant Human OX40 Ligand/TNFSF4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human OX40 Ligand/TNFSF4 Protein, CF has been validated for the following applications: Bioactivity, Binding Activity.

target :

OX40 Ligand/TNFSF4

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity, Binding Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

28-34 kDa, reducing conditions

theoretical molecular weight :

18 kDa

gene symbol :

TNFSF4

details of functionality :

Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with human OX40/TNFRSF4. Muller, N. et al . (2008) FEBS J. 275 :2296. The ED50 for this effect is typically 1-5 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human OX40/TNFRSF4 Fc Chimera (Catalog # 3388-OX ) is immobilized at 10 ng/mL, the concentration of Recombinant Human OX40 Ligand/TNFSF4 that produces 50% optimal binding response is found to be approximately 0.5-3 ng/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human OX40 Ligand/TNFSF4 Protein Bioactivity

accessionNumbers :

Q6FGS4

applications :

Bioactivity, Binding Activity

source :

NS0-derived Recombinant Human OX40 Ligand/TNFSF4 Protein, CF

USD :

432 USD

alt names :

CD134 ligand, CD134L, CD252, CD252 antigen, Glycoprotein Gp34, gp34, OX40 antigen ligand, OX40 ligand, OX40L, OX-40L, OX4OL, TAX transcriptionally-activated glycoprotein 1, tax-transcriptionally activated glycoprotein 1 (34kD), tax-transcriptionally activated glycoprotein 1, 34kD, TNFSF4, tumor necrosis factor (ligand) superfamily, member 4, tumor necrosis factor ligand superfamily member 4, TXGP1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage