Recombinant Human EN-RAGE Protein, CF | R&D Systems 1052-ER product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human EN-RAGE Protein, CF

catalog :

1052-ER

quantity :

50 ug

price :

359 USD

citations: 2

Reference
Yan L, Mathew L, Chellan B, Gardner B, Earley J, Puri T, et al. S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products-dependent manner. Arterioscler Thromb Vasc Biol. 2014;34:1399-411 pubmed publisher
Chellan B, Yan L, Sontag T, Reardon C, HOFMANN BOWMAN M. IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1. J Lipid Res. 2014;55:443-54 pubmed publisher

product information

brand :

R&D Systems

master code :

1052-ER

SKU :

1052-ER-050

product name :

Recombinant Human EN-RAGE Protein, CF

description :

The Recombinant Human EN-RAGE Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human EN-RAGE Protein, CF has been validated for the following applications: Bioactivity.

target :

EN-RAGE/S100A12

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

8 kDa, reducing condtions

theoretical molecular weight :

10.6 kDa

gene symbol :

S100A12

details of functionality :

Measured by its binding ability in a functional ELISA. When rhRAGE/Fc Chimera (Catalog # 1145-RG) is coated at 2 µg/mL (100 µL/well), rhS100A12 binds with an apparent KD 30 nM. . This protein also enhances integrin activation on neutrophils as measured by flow cytometric analysis using beta 2 integrin activation reporter antibody mAb 24. . Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1052-ER

accessionNumbers :

P80511

applications :

Bioactivity

source :

E. coli -derived human EN-RAGE/S100A12 protein Met1-Glu92

2020 USD :

359

2021 USD :

359 USD

alt names :

CAAF1, CAAF1Neutrophil S100 protein, CAAFI, CAGC, CAGCS100, CAGCS100 calcium binding protein A12 (calgranulin C), Calcium-binding protein in amniotic fluid 1, Calgranulin C, Calgranulin-C, CGRPEN-RAGE, ENRAGE, Extracellular newly identified RAGE-binding protein, MRP6, p6calgranulin C, protein S100-A12, S100 calcium binding protein A12, S100 calcium-binding protein A12, S100 calcium-binding protein A12 (calgranulin C), S100A12

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.