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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human EN-RAGE Protein, CF
catalog :
1052-ER-050
quantity :
50 ug
price :
456 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Yan L, Mathew L, Chellan B, Gardner B, Earley J, Puri T, et al. S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products-dependent manner. Arterioscler Thromb Vasc Biol. 2014;34:1399-411 pubmed publisher
Chellan B, Yan L, Sontag T, Reardon C, HOFMANN BOWMAN M. IL-22 is induced by S100/calgranulin and impairs cholesterol efflux in macrophages by downregulating ABCG1. J Lipid Res. 2014;55:443-54 pubmed publisher
product information
brand :
R&D Systems
master code :
1052-ER
SKU :
1052-ER-050
product name :
Recombinant Human EN-RAGE Protein, CF
unit size :
50 ug
seo description :
The Recombinant Human EN-RAGE Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human EN-RAGE Protein, CF has been validated for the following applications: Bioactivity.
target :
EN-RAGE/S100A12
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
8 kDa, reducing condtions
theoretical molecular weight :
10.6 kDa
gene symbol :
S100A12
details of functionality :
Measured by its binding ability in a functional ELISA. When rhRAGE/Fc Chimera (Catalog # 1145-RG) is coated at 2 ╡g/mL (100 ╡L/well), rhS100A12 binds with an apparent KD 30 nM. . This protein also enhances integrin activation on neutrophils as measured by flow cytometric analysis using ▀2 integrin activation reporter antibody mAb 24. . Optimal dilutions should be determined by each laboratory for each application.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P80511
applications :
Bioactivity
source :
E. coli-derived Recombinant Human EN-RAGE Protein, CF
USD :
456 USD
alt names :
CAAF1, CAAF1Neutrophil S100 protein, CAAFI, CAGC, CAGCS100, CAGCS100 calcium binding protein A12 (calgranulin C), Calcium-binding protein in amniotic fluid 1, Calgranulin C, Calgranulin-C, CGRPEN-RAGE, ENRAGE, Extracellular newly identified RAGE-binding protein, MRP6, p6calgranulin C, protein S100-A12, S100 calcium binding protein A12, S100 calcium-binding protein A12, S100 calcium-binding protein A12 (calgranulin C), S100A12
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.