Recombinant Human ADAM8 Protein, CF | R&D Systems 1031-AD-020 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ADAM8 Protein, CF

catalog :

1031-AD-020

quantity :

20 ug

price :

470 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Pianetti S, Miller K, Chen H, Althouse S, Cao S, Michael S, et al. ADAM8 is expressed widely in breast cancer and predicts poor outcome in hormone receptor positive, HER-2 negative patients. Cancer Cell Int. 2023;23:165 pubmed publisher
Mi Z, Kuo M, Kuo P. RNA Aptamer Targeting of Adam8 in Cancer Growth and Metastasis. Cancers (Basel). 2023;15: pubmed publisher
Johansson M, Khanna M, Bortnov V, Annis D, Nguyen C, Mosher D. IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration. Clin Exp Allergy. 2017;47:1263-1274 pubmed publisher
Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia A, et al. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015;6:6175 pubmed publisher
McDonald A, Dibble J, Evans E, Millhauser G. A new paradigm for enzymatic control of ?-cleavage and ?-cleavage of the prion protein. J Biol Chem. 2014;289:803-13 pubmed publisher
Gómez Gaviro M, Domínguez Luis M, Canchado J, Calafat J, Janssen H, Lara Pezzi E, et al. Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J Immunol. 2007;178:8053-63 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1031-AD

SKU :

1031-AD-020

product name :

Recombinant Human ADAM8 Protein, CF

Description :

The Recombinant Human ADAM8 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ADAM8 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

ADAM8

category :

Proteins and Enzymes

unit size :

20 ug

buffer :

Supplied as a 0.2 µm filtered solution in Glycerol, Tris, NaCl and CaCl2.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

42 kDa, reducing conditions

theoretical molecular weight :

38 kDa

gene symbol :

ADAM8

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2 (Catalog # ES003 ). The specific activity is 1 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P78325

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human ADAM8 Protein

USD :

470 USD

alt names :

a disintegrin and metalloproteinase domain 8, ADAM 8, ADAM metallopeptidase domain 8, CD156a, CD156a antigen, CD156human leukocyte differentiation antigen, Cell surface antigen MS2, EC 3.4.24, EC 3.4.24.-, MGC134985, MS2, MS2disintegrin and metalloproteinase domain-containing protein 8

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage