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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TNF-alpha (HEK293-expressed) Protein, CF
catalog :
10291-TA-020
quantity :
20 ug (also 50 ug, 100 ug, 250 ug, 500 ug, 1 mg)
price :
207 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Sun Y, Maggs L, Panda A, Wright S, Cicerchia A, Jenney A, et al. TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids. Cancer Immunol Res. 2025;13:210-228 pubmed publisher
Majocchi S, Lloveras P, Nouveau L, Legrand M, Viandier A, Malinge P, et al. NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control. Cancer Immunol Res. 2025;13:365-383 pubmed publisher
Li Y, Li T, Qiao Q, Zhang M, Tong M, Xu L, et al. Polymeric immunoglobulin receptor promotes Th2 immune response in the liver by increasing cholangiocytes derived IL-33: a diagnostic and therapeutic biomarker of biliary atresia. EBioMedicine. 2024;108:105344 pubmed publisher
Hayderi A, Zegeye M, Meydan S, Sirsj xf6 A, Kumawat A, Ljungberg L. TNF Induces Laminin-332-Encoding Genes in Endothelial Cells and Laminin-332 Promotes an Atherogenic Endothelial Phenotype. Int J Mol Sci. 2024;25: pubmed publisher
Ulrich A, Wu Y, Draisma H, Wharton J, Swietlik E, Cebola I, et al. Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension. Nat Commun. 2024;15:330 pubmed publisher
Mijit M, Kpenu E, Chowdhury N, Gampala S, Wireman R, Liu S, et al. In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer. Redox Biol. 2024;69:102977 pubmed publisher
Barilli A, Recchia Luciani G, Visigalli R, Sala R, Soli M, Dall Asta V, et al. Cytokine-Induced iNOS in A549 Alveolar Epithelial Cells: A Potential Role in COVID-19 Lung Pathology. Biomedicines. 2023;11: pubmed publisher
Lass xe9 M, El Saghir J, Berthier C, Eddy S, Fischer M, Laufer S, et al. An integrated organoid omics map extends modeling potential of kidney disease. Nat Commun. 2023;14:4903 pubmed publisher
Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, et al. Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature. 2023;: pubmed publisher
Wang S, Zhang Q, Lu D, Fang Y, Yan X, Chen J, et al. GPR84 regulates pulmonary inflammation by modulating neutrophil functions. Acta Pharmacol Sin. 2023;44:1665-1675 pubmed publisher
Salva S, Tiscornia I, Gutiérrez F, Alvarez S, Bollati Fogolin M. Lactobacillus rhamnosus postbiotic-induced immunomodulation as safer alternative to the use of live bacteria. Cytokine. 2021;146:155631 pubmed publisher
product information
master code :
10291-TA
SKU :
10291-TA-020
product name :
Recombinant Human TNF-alpha (HEK293-expressed) Protein, CF
unit size :
20 ug (also 50 ug, 100 ug, 250 ug, 500 ug, 1 mg)
description :
The Recombinant Human TNF-alpha (HEK293-expressed) Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human TNF-alpha (HEK293-expressed) Protein, CF has been validated for the following applications: Bioactivity.
target :
TNF-alpha
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
14-18 kDa, under reducing conditions
theoretical molecular weight :
17 kDa
details of functionality :
Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycináD. Matthews,áN. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect is 20-100 pg/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P01375
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived human TNF-alpha protein Val77-Leu233
source short :
HEK293
extended description :
Analyzed by SEC-MALS
USD :
207 USD
product details :
Analyzed by SEC-MALS
alt names :
APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-a, TNFA, TNFalpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFG1F, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.