Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF | R&D Systems 1022-PL-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF

catalog :

1022-PL-100

quantity :

100 ug (also 1 mg)

price :

434 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Hurrell B, Helou D, Howard E, Painter J, Shafiei Jahani P, Sharpe A, et al. PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability. Nat Commun. 2022;13:5118 pubmed publisher
Garo L, Ajay A, Fujiwara M, Beynon V, Kuhn C, Gabriely G, et al. Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity. Cell Rep. 2019;28:3353-3366.e5 pubmed publisher
Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco L, et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med. 2014;211:943-59 pubmed publisher
Butte M, Keir M, Phamduy T, Sharpe A, Freeman G. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111-22 pubmed

image

image 1 :

Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1022-PL

SKU :

1022-PL-100

product name :

Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF

Description :

The Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

PD-L2/B7-DC

category :

Proteins and Enzymes

unit size :

100 ug (also 1 mg)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

76 kDa, reducing conditions

theoretical molecular weight :

49 kDa (monomer)

gene symbol :

Pdcd1lg2

details of functionality :

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated mouse T cells. The ED50 for this effect is 1-6 µg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9WUL5

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse PD-L2/B7-DC Fc Chimera Protein

USD :

434 USD

alt names :

B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, Butyrophilin-like Protein, CD273, CD273 antigen, CD273PD-1 ligand 2, MGC142240, PD-1-ligand 2, PDCD1L2MGC142238, PDCD1LG2, PDL2, PDL2B7DC, PD-L2PDCD1 ligand 2, programmed cell death 1 ligand 2, Programmed death ligand 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage