product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse PD-1 Fc Chimera Protein, CF
catalog :
1021-PD-100
quantity :
100 ug
price :
443 USD
more info or order :
citations: 8
Reference
Mehdi A, Attias M, Arakelian A, Piccirillo C, Szyf M, Rabbani S. Co-Targeting Luminal B Breast Cancer with S-Adenosylmethionine and Immune Checkpoint Inhibitor Reduces Primary Tumor Growth and Progression, and Metastasis to Lungs and Bone. Cancers (Basel). 2022;15: pubmed publisher
Edwards C, Sette A, Cox C, Di Fiore B, Wyre C, Sydoruk D, et al. The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity. Br J Cancer. 2021;: pubmed publisher
Guiteras J, de Ramon L, Crespo E, Bolaños N, Barceló Batllori S, Martinez Valenzuela L, et al. Dual and Opposite Costimulatory Targeting with a Novel Human Fusion Recombinant Protein Effectively Prevents Renal Warm Ischemia Reperfusion Injury and Allograft Rejection in Murine Models. Int J Mol Sci. 2021;22: pubmed publisher
Silva Pilipich N, Martisova E, Ballesteros Briones M, Hervas Stubbs S, Casares N, Gonzalez Sapienza G, et al. Long-Term Systemic Expression of a Novel PD-1 Blocking Nanobody from an AAV Vector Provides Antitumor Activity without Toxicity. Biomedicines. 2020;8: pubmed publisher
Jacobs L, De Smidt E, Geukens N, Declerck P, Hollevoet K. DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct Exposure. Mol Ther. 2020;28:1068-1077 pubmed publisher
Matsumura T, Sugawara Y, Yutani M, Amatsu S, Yagita H, Kohda T, et al. Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity. Nat Commun. 2015;6:6255 pubmed publisher
Butte M, Keir M, Phamduy T, Sharpe A, Freeman G. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111-22 pubmed
Arnett H, Escobar S, Gonzalez Suarez E, Budelsky A, Steffen L, Boiani N, et al. BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation. J Immunol. 2007;178:1523-33 pubmed
product information
master code :
1021-PD
SKU :
1021-PD-100
product name :
Recombinant Mouse PD-1 Fc Chimera Protein, CF
unit size :
100 ug
description :
The Recombinant Mouse PD-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse PD-1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
PD-1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Tris-HCL, NaCl and EDTA with Trehalose.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
66 kDa, reducing conditions
theoretical molecular weight :
43 kDa (monomer)
gene symbol :
Pdcd1
details of functionality :
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse PD-1 Fc Chimera at 1 ╡g/mL (100 ╡L/well) can bind Recombinant Mouse B7-H1/PD-L1 Fc Chimera (Catalog # 1019-B7 ) with an ED50 of 0.16-0.8 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse PD-1 Fc Chimera Protein Bioactivity
accessionNumbers :
Q02242
applications :
Binding Activity
source long :
Mouse myeloma cell line, NS0-derived mouse PD-1 protein Mouse PD-1 (Leu25-Gln167) Accession # Q02242 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
source short :
NS0
USD :
443 USD
alt names :
CD279, CD279 antigen, hPD-1, PD1, PD1hPD-l, PDCD1, programmed cell death 1, programmed cell death protein 1, Protein PD-1, SLEB2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.