product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TRAIL R2/TNFRSF10B Fc Chimera Protein, CF
catalog :
10140-T2-100
quantity :
100 ug
price :
443 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Yagolovich A, Isakova A, Artykov A, Vorontsova Y, Mazur D, Antipova N, et al. DR5-Selective TRAIL Variant DR5-B Functionalized with Tumor-Penetrating iRGD Peptide for Enhanced Antitumor Activity against Glioblastoma. Int J Mol Sci. 2022;23: pubmed publisher
Lee M, Kim D, Eom J, Lee J, Sung K, Koo H, et al. Dual role of ERK2/NF-κB signaling in TRAIL sensitivity. Am J Cancer Res. 2022;12:3373-3389 pubmed
Natesampillai S, Paim A, Cummins N, Chandrasekar A, Bren G, Lewin S, et al. TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection. J Immunol. 2019;: pubmed publisher
product information
master code :
10140-T2
SKU :
10140-T2-100
product name :
Recombinant Human TRAIL R2/TNFRSF10B Fc Chimera Protein, CF
unit size :
100 ug
description :
The Recombinant Human TRAIL R2/TNFRSF10B Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human TRAIL R2/TNFRSF10B Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
TRAIL R2/TNFRSF10B
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
54-61 kDa, under reducing conditions
theoretical molecular weight :
44 kDa
details of functionality :
Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 0.75-6 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human TRAIL R2/TNFRSF10B Fc Chimera Protein Inhibition Activity
accessionNumbers :
AAH01281.1
applications :
Bioactivity
source long :
Chinese Hamster Ovary cell line, CHO-derived human TRAIL R2/TNFRSF10B protein Human TRAIL R2/TNFRSF10B (Ala54-Ser210) Accession # AAH01281.1 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
source short :
CHO
USD :
443 USD
alt names :
CD262, CD262 antigen, death domain containing receptor for TRAIL/Apo-2L, Death receptor 5, DR5, DR5TRICK2B, Fas-like protein, KILLER/DR5, KILLERapoptosis inducing protein TRICK2A/2B, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAILR2, TRAIL-R2apoptosis inducing receptor TRAIL-R2, TRAILR2cytotoxic TRAIL receptor-2, TRICK2, TRICK2A, TRICKB, tumor necrosis factor receptor superfamily member 10B, tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9, ZTNFR9
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.