Recombinant Human Cathepsin D Protein, CF | R&D Systems 1014-AS product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Cathepsin D Protein, CF

catalog :

1014-AS

quantity :

10 ug

price :

349 USD

citations: 8

Reference
Lee C, Stankowski J, Chew J, Cook C, Lam Y, Almeida S, et al. The lysosomal protein cathepsin L is a progranulin protease. Mol Neurodegener. 2017;12:55 pubmed publisher
Hsieh Y, Chien K, Yang I, Lee I, Wu C, Huang T, et al. Oxidation of protein-bound methionine in Photofrin-photodynamic therapy-treated human tumor cells explored by methionine-containing peptide enrichment and quantitative proteomics approach. Sci Rep. 2017;7:1370 pubmed publisher
Ivry S, Sharib J, Dominguez D, Roy N, Hatcher S, Yip Schneider M, et al. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017;23:4865-4874 pubmed publisher
Khalkhali Ellis Z, Goossens W, Margaryan N, Hendrix M. Cleavage of Histone 3 by Cathepsin D in the involuting mammary gland. PLoS ONE. 2014;9:e103230 pubmed publisher
Derocq D, Prebois C, Beaujouin M, Laurent Matha V, Pattingre S, Smith G, et al. Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis. Oncogene. 2012;31:3202-12 pubmed publisher
Zou F, Schäfer N, Palesch D, Brücken R, Beck A, Sienczyk M, et al. Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients. PLoS ONE. 2011;6:e22815 pubmed publisher
Ahmed R, Holler C, Webb R, Li F, Beckett T, Murphy M. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem. 2010;112:1045-53 pubmed publisher
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed

product information

brand :

R&D Systems

master code :

1014-AS

SKU :

1014-AS-010

product name :

Recombinant Human Cathepsin D Protein, CF

description :

The Recombinant Human Cathepsin D Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin D Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Cathepsin D

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

50 kDa, reducing conditions

theoretical molecular weight :

44 kDa

gene symbol :

CTSD

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The specific activity is 350 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1014-AS

accessionNumbers :

P07339.1

applications :

Enzyme Activity

source :

Mouse myeloma cell line, NS0-derived human Cathepsin D protein Leu21-Leu412, with a C-terminal 10-His tag

2020 USD :

349

2021 USD :

349 USD

alt names :

cathepsin D, cathepsin D (lysosomal aspartyl protease), CPSD, CTSD, EC 3.4.23, EC 3.4.23.5, lysosomal aspartyl peptidase, lysosomal aspartyl protease, MGC2311, neuronal 10

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.