product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Cathepsin D Protein, CF
catalog :
1014-AS-010
quantity :
10 ug
price :
443 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Kozak A, Mikhaylov G, Khodakivskyi P, Goun E, Turk B, Vasiljeva O. A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A. Pharmaceutics. 2023;15: pubmed publisher
Ding P, Xu Y, Li L, Lv X, Li L, Chen J, et al. Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis. Cell Rep. 2022;39:110851 pubmed publisher
Skokowa J, Hernandez Alvarez B, Coles M, Ritter M, Nasri M, Haaf J, et al. A topological refactoring design strategy yields highly stable granulopoietic proteins. Nat Commun. 2022;13:2948 pubmed publisher
Lee C, Stankowski J, Chew J, Cook C, Lam Y, Almeida S, et al. The lysosomal protein cathepsin L is a progranulin protease. Mol Neurodegener. 2017;12:55 pubmed publisher
Hsieh Y, Chien K, Yang I, Lee I, Wu C, Huang T, et al. Oxidation of protein-bound methionine in Photofrin-photodynamic therapy-treated human tumor cells explored by methionine-containing peptide enrichment and quantitative proteomics approach. Sci Rep. 2017;7:1370 pubmed publisher
Ivry S, Sharib J, Dominguez D, Roy N, Hatcher S, Yip Schneider M, et al. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017;23:4865-4874 pubmed publisher
Khalkhali Ellis Z, Goossens W, Margaryan N, Hendrix M. Cleavage of Histone 3 by Cathepsin D in the involuting mammary gland. PLoS ONE. 2014;9:e103230 pubmed publisher
Derocq D, Prebois C, Beaujouin M, Laurent Matha V, Pattingre S, Smith G, et al. Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis. Oncogene. 2012;31:3202-12 pubmed publisher
Zou F, Schäfer N, Palesch D, Brücken R, Beck A, Sienczyk M, et al. Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients. PLoS ONE. 2011;6:e22815 pubmed publisher
Ahmed R, Holler C, Webb R, Li F, Beckett T, Murphy M. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem. 2010;112:1045-53 pubmed publisher
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed
product information
master code :
1014-AS
SKU :
1014-AS-010
product name :
Recombinant Human Cathepsin D Protein, CF
unit size :
10 ug
description :
The Recombinant Human Cathepsin D Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin D Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Cathepsin D
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
50 kDa, reducing conditions
theoretical molecular weight :
44 kDa
gene symbol :
CTSD
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The specific activity is 350 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P07339.1
applications :
Enzyme Activity
source long :
Mouse myeloma cell line, NS0-derived human Cathepsin D protein Leu21-Leu412, with a C-terminal 10-His tag
source short :
NS0
USD :
443 USD
alt names :
cathepsin D, cathepsin D (lysosomal aspartyl protease), CPSD, CTSD, EC 3.4.23, EC 3.4.23.5, lysosomal aspartyl peptidase, lysosomal aspartyl protease, MGC2311, neuronal 10
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.