Recombinant Human ErbB2/Her2 His-tag Protein, CF | R&D Systems 10126-ER-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ErbB2/Her2 His-tag Protein, CF

catalog :

10126-ER-050

quantity :

50 ug

price :

408 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Yang Y, Yang H, Alcaina Y, Puc J, Birt A, Vedvyas Y, et al. Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models. Nat Commun. 2023;14:2068 pubmed publisher
Shaimerdenova M, Ayupova T, Bekmurzayeva A, Sypabekova M, Ashikbayeva Z, Tosi D. Spatial-Division Multiplexing Approach for Simultaneous Detection of Fiber-Optic Ball Resonator Sensors: Applications for Refractometers and Biosensors. Biosensors (Basel). 2022;12: pubmed publisher
Liu Y, Lee A, Nguyen A, Maynard J. An antibody Fc engineered for conditional antibody-dependent cellular cytotoxicity at the low tumor microenvironment pH. J Biol Chem. 2022;298:101798 pubmed publisher

image

image 1 :

Recombinant Human ErbB2/Her2 His-tag Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

10126-ER

SKU :

10126-ER-050

product name :

Recombinant Human ErbB2/Her2 His-tag Protein, CF

description :

The Recombinant Human ErbB2/Her2 His-tag Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human ErbB2/Her2 His-tag Protein, CF has been validated for the following applications: Bioactivity.

target :

ErbB2/Her2

unit size :

50 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

93-108 kDa, under reducing conditions

theoretical molecular weight :

70 kDa

details of functionality :

Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. Brodowicz, T. et al . (1997) Int. J. Cancer 73 :875. The ED50 for this effect is 0.3-1.2 µg/mL in the presence of 0.6 µg/mL Human ErbB2/Her2 Antibody (Trastuzumab, Catalog # MAB9589 ).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P04626-1

applications :

Bioactivity

product keywords :

10126-ER, rhErbB2 His, hErbB2, CF, carrier-free, carrier free, 10126ER, ErbB 2, Erb2, Receptor Tyrosine Kinase, RTK, v-erb-b2, c-erb B2, HER-2/neu, breast cancer, EGFR, EGF Receptor, EGFR Kinase, EGF Family, cytokine, cytokines

source :

HEK293-derived Recombinant Human ErbB2/Her2 His-tag Protein, CF

USD :

400

USD 2025 :

408 USD

alt names :

CD340, CD340 antigen, c-erb B2/neu protein, EC 2.7.10, EGFR2, HER2, HER-2, HER2EC 2.7.10.1, herstatin, Metastatic lymph node gene 19 protein, MLN 19, MLN19, Neu Oncogene, NEUHER-2/neu, neuroblastoma/glioblastoma derived oncogene homolog, NGL, NGLTKR1, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)

more info or order :

R&D Systems product webpage