This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Pro-TNF-alpha Fusion Protein, CF
catalog :
1012-PS
quantity :
10 ug
price :
359 USD
citations: 3
Reference
Schaal J, Tran D, Subramanian A, Patel R, Laragione T, Roberts K, et al. Suppression and resolution of autoimmune arthritis by rhesus ?-defensin-1, an immunomodulatory macrocyclic peptide. PLoS ONE. 2017;12:e0187868 pubmed publisher
Marshall D, Lyman S, McCauley S, Kovalenko M, Spangler R, Liu C, et al. Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer. PLoS ONE. 2015;10:e0127063 pubmed publisher
Vandenbroucke R, Dejonckheere E, Van Hauwermeiren F, Lodens S, De Rycke R, Van Wonterghem E, et al. Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO Mol Med. 2013;5:1000-16 pubmed publisher
product information
brand :
R&D Systems
master code :
1012-PS
SKU :
1012-PS-010
product name :
Recombinant Pro-TNF-alpha Fusion Protein, CF
description :
The Recombinant Pro-TNF-alpha Fusion Protein, CF from R&D Systems is derived from E. coli. The Recombinant Pro-TNF-alpha Fusion Protein, CF has been validated for the following applications: Enzyme Activity.
target :
TNF-alpha
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Urea, NaCl, NaH2PO4 and DTT.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
42 kDa, reducing conditions
theoretical molecular weight :
45 kDa
gene symbol :
TNF
details of functionality :
Measured by its ability to be used as a protein substrate for TACE/ADAM17. Under the described conditions TACE/ADAM17 will cleave pro-TNF-alpha to produce mature TNF-alpha .
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
1012-PS
accessionNumbers :
P01375
applications :
Enzyme Activity
source :
E. coli -derived human TNF-alpha protein Bacterial Protein Fusion Partner Human Pro-TNF-alpha (Gly57-Ala76) Accession # P01375 Human Mature TNF-alpha (Val77-Leu233) Accession # P01375 N-terminus C-terminus
2020 USD :
359
2021 USD :
359 USD
alt names :
APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-a, TNFA, TNFalpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFG1F, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.