Recombinant Rat UNC5H2/UNC5B Fc Chimera Protein, CF | R&D Systems 1006-UN-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Rat UNC5H2/UNC5B Fc Chimera Protein, CF

catalog :

1006-UN-050

quantity :

50 ug

price :

468 USD

citations: 3

Reference
Boyé K, Geraldo L, Furtado J, Pibouin Fragner L, Poulet M, Kim D, et al. Endothelial Unc5B controls blood-brain barrier integrity. Nat Commun. 2022;13:1169 pubmed publisher
Brunet I, Gordon E, Han J, Cristofaro B, Broqueres You D, Liu C, et al. Netrin-1 controls sympathetic arterial innervation. J Clin Invest. 2014;124:3230-40 pubmed publisher
Ramkhelawon B, Hennessy E, Ménager M, Ray T, Sheedy F, Hutchison S, et al. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med. 2014;20:377-84 pubmed publisher

product information

master code :

1006-UN

SKU :

1006-UN-050

product name :

Recombinant Rat UNC5H2/UNC5B Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Rat UNC5H2/UNC5B Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Rat UNC5H2/UNC5B Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

UNC5H2/UNC5B

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Rat

observed molecular weight :

85-90 kDa, reducing conditions

theoretical molecular weight :

65 kDa (monomer)

gene symbol :

Unc5b

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rrUNC5H2/Fc Chimera at 5 ╡g/mL (100 ╡L/well) can bind rcNetrin-1 with a linear range of 6-400áng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

O08722

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived rat UNC5H2/UNC5B protein Rat UNC5H2 (Gly27 - Asp373) Accession # O08722 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

468 USD

alt names :

p53RDL1, p53-regulated receptor for death and life protein 1, Protein unc-5 homolog 2, Protein unc-5 homolog B, transmembrane receptor Unc5H2, unc5 (C.elegans homolog) b, unc-5 homolog 2, unc-5 homolog B (C. elegans), UNC5B, UNC5H2netrin receptor UNC5B

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.