product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-12 (linked heterodimer) Protein, CF
catalog :
10018-IL-010
quantity :
10 ug (also 20 ug, 50 ug, 100 ug)
price :
355 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Arias A, Neehus A, Ogishi M, Meynier V, Krebs A, Lazarov T, et al. Tuberculosis in otherwise healthy adults with inherited TNF deficiency. Nature. 2024;633:417-425 pubmed publisher
Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, et al. Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells. iScience. 2021;24:103433 pubmed publisher
Gao Y, Sun W, Cha X, Wang H. 'Psoriasis 1' reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation. Int J Mol Med. 2020;46:1538-1550 pubmed publisher
product information
master code :
10018-IL
SKU :
10018-IL-010
product name :
Recombinant Human IL-12 (linked heterodimer) Protein, CF
unit size :
10 ug (also 20 ug, 50 ug, 100 ug)
description :
The Recombinant Human IL-12 (linked heterodimer) Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human IL-12 (linked heterodimer) Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-12
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
63-75 kDa, under reducing conditions.
theoretical molecular weight :
59 kDa
details of functionality :
Measured in a cell proliferation assay using PHA-stimulated human T lymphoblasts. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 0.01-0.05 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human IL-12 (linked heterodimer) Protein Bioactivity
accessionNumbers :
P29460.1 (IL-12p40), P29459.2 (IL-12p35)
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived human IL-12 protein Human IL-12p40 (Ile23-Ser328) Accession # P29460.1 GSGSSRGGSGSGGSGGGGSK Human IL-12p35 (Arg23-Ser219) Accession # P29459.2 N-terminus C-terminus
source short :
HEK293
extended description :
GS Linker, Defined heterodimer stoichiometry.
USD :
355 USD
product details :
GS Linker, Defined heterodimer stoichiometry.
alt names :
CLMF p35, CLMF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit, IL12, IL-12 subunit p35, IL-12, subunit p35, IL12A, interleukin 12, p35, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35), interleukin-12 alpha chain, interleukin-12 subunit alpha, natural killer cell stimulatory factor 1, 35 kD subunit, NF cell stimulatory factor chain 1, NK cell stimulatory factor chain 1, NKSF1, p35
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, <= -20 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, <= -20 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.