Recombinant Human IL-12 (linked heterodimer) Protein, CF | R&D Systems 10018-IL-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-12 (linked heterodimer) Protein, CF

catalog :

10018-IL-010

quantity :

10 ug (also 20 ug, 50 ug, 100 ug)

price :

355 USD

citations: 3

Reference
Arias A, Neehus A, Ogishi M, Meynier V, Krebs A, Lazarov T, et al. Tuberculosis in otherwise healthy adults with inherited TNF deficiency. Nature. 2024;633:417-425 pubmed publisher
Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, et al. Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells. iScience. 2021;24:103433 pubmed publisher
Gao Y, Sun W, Cha X, Wang H. 'Psoriasis 1' reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation. Int J Mol Med. 2020;46:1538-1550 pubmed publisher

product information

master code :

10018-IL

SKU :

10018-IL-010

product name :

Recombinant Human IL-12 (linked heterodimer) Protein, CF

unit size :

10 ug (also 20 ug, 50 ug, 100 ug)

description :

The Recombinant Human IL-12 (linked heterodimer) Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human IL-12 (linked heterodimer) Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-12

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

63-75 kDa, under reducing conditions.

theoretical molecular weight :

59 kDa

details of functionality :

Measured in a cell proliferation assay using PHA-stimulated human T lymphoblasts. Symons, J.A. etáal . (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etáal . (eds): IRL Press. 272. The ED50 for this effect is 0.01-0.05 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human IL-12 (linked heterodimer) Protein Bioactivity

accessionNumbers :

P29460.1 (IL-12p40), P29459.2 (IL-12p35)

applications :

Bioactivity

source long :

Human embryonic kidney cell, HEK293-derived human IL-12 protein Human IL-12p40 (Ile23-Ser328) Accession # P29460.1 GSGSSRGGSGSGGSGGGGSK Human IL-12p35 (Arg23-Ser219) Accession # P29459.2 N-terminus C-terminus

source short :

HEK293

extended description :

GS Linker, Defined heterodimer stoichiometry.

USD :

355 USD

product details :

GS Linker, Defined heterodimer stoichiometry.

alt names :

CLMF p35, CLMF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit, IL12, IL-12 subunit p35, IL-12, subunit p35, IL12A, interleukin 12, p35, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35), interleukin-12 alpha chain, interleukin-12 subunit alpha, natural killer cell stimulatory factor 1, 35 kD subunit, NF cell stimulatory factor chain 1, NK cell stimulatory factor chain 1, NKSF1, p35

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, <= -20 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, <= -20 ░C under sterile conditions after reconstitution.