Anti-Myoferlin Antibody | QED Bioscience 90020 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Myoferlin Antibody

catalog :

90020

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7D2

The same clone is also sold as:

Abcam: ab76746
OriGene: AM10201PU-N

reactivity :

human, mouse

product information

CATALOG NUMBER :

90020

PRODUCT NAME :

Anti-Myoferlin Antibody

NAME+SKU :

Anti-Myoferlin Antibody (90020)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Myoferlin Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Myoferlin

SPECIES REACTIVITY :

Human, mouse

TARGET NAME :

Myoferlin

UNIPROT :

Q9NZM1

LOCATION :

Cell membrane; Single-pass type II membrane protein. Nucleus membrane; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Note=Concentrated at the membrane sites of both myoblast-myoblast and myoblast-myotube fusions. Detected at the plasmalemma in endothelial cells lining intact blood vessels (By similarity). Found at nuclear and plasma membranes. Enriched in undifferentiated myoblasts near the plasma membrane in puncate structures.

PROTEIN NAME :

Myoferlin

ALTERNATIVE NAMES :

Fer-1-like protein 3

GENE NAME :

MYOF

CLONALITY :

Monoclonal

FORM :

Lyophilized

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

348.6

SKU SIZE 1 :

90020

APPLICATIONS :

WB, ICC

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-10ug/ml. A band of ~230kDa is detected. Immunocytochemistry: use at 1- 20ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG2a

CLONE ID :

7D2

IMMUNOGEN :

Synthetic peptide derived from the N-terminal domain of the human FER1L3 protein. Accession no. Q9NZM1.

RESEARCH AREA :

Cancer research

FORMULATION :

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.

BUFFER :

Tris Buffer

TARGET BACKGROUND :

Ferlin proteins have been implicated in vesicle trafficking in a variety of physio- logical settings. All mammalian ferlins derive their names based on homology to the C. elegans protein FER-1 (FERtilization defective-1). FER1L3 (myoferlin, MYOF), has not yet been directly associated with a distinct mammalian disorder, but recent microarray and proteomic studies in the cancer literature have reported overexpression of MYOF in breast cancer specimens and relevant cell lines. Therefore, MYOF may be an important protein in breast cancer cells for their mobilization during cellular migration and/or invasion.

FUNCTION :

Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}.

STORAGE CONDITION :

This product is stable for at least one (1) year at -20C to -70C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human and mouse FER1L3.

Image Name_1 :

qed-bioscience-anti-myoferlin-antibody-90020-1.jpg

Applications 1 :