Anti-Excitatory Amino Acid Transporter 1 Antibody | QED Bioscience 90014 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Excitatory Amino Acid Transporter 1 Antibody

catalog :

90014

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G7c2

reactivity :

rat

product information

CATALOG NUMBER :

90014

PRODUCT NAME :

Anti-Excitatory Amino Acid Transporter 1 Antibody

NAME+SKU :

Anti-Excitatory Amino Acid Transporter 1 Antibody (90014)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Excitatory Amino Acid Transporter 1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Excitatory Amino Acid Transporter 1

SPECIES REACTIVITY :

Rat

TARGET NAME :

Excitatory Amino Acid Transporter 1

UNIPROT :

P24942

LOCATION :

Cell membrane , Multi-pass membrane protein.

PROTEIN NAME :

Excitatory amino acid transporter 1

ALTERNATIVE NAMES :

Glial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 1, GLAST, GLAST-1, Solute carrier family 1 member 3

GENE NAME :

Slc1a3

CLONALITY :

Monoclonal

FORM :

Lyophilized

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

348.6

SKU SIZE 1 :

90014

APPLICATIONS :

WB, IHC, ELISA

APPLICATION INSTRUCTIONS :

ELISA: use at 0.1-2ug/ml. Immunoblotting: use at 1-5ug/ml. A band of ~60kDa is detected. Immunohistochemistry: Use at 2- 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

2G7C2

IMMUNOGEN :

Synthetic peptide derived from the C-terminal domain of rat EAAT1. Accession no. P24942.

RESEARCH AREA :

Neuroscience

FORMULATION :

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.

BUFFER :

Tris Buffer

TARGET BACKGROUND :

Excitatory amino-acid transporters (EAATs), also known as glutamate transporters, belong to the family of neurotransmitter transporters. EAATs serve to terminate the excitatory signal by removal of glutamate from the neuronal synapse into neuroglia and neurons. After glutamate is released as the result of an action potential, glutamate transporters quickly remove it from the extracellular space to keep its levels low, thereby terminating the synaptic transmission. The activity of glutamate transporters also allows glutamate to be recycled for repeated release. Glutamate transporters also transport aspartate and are present in virtually all peripheral tissue. They exhibit stereoselectivity for L-glutamate but transport both L- and D-aspartate.

FUNCTION :

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1279699, PubMed:8387171). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {UniProtKB:O57321, UniProtKB:P56564, PubMed:1279699, PubMed:8387171}.

STORAGE CONDITION :

This product is stable for at least one (1) year at -20C to -70C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.

SPECIFICITY :

This antibody reacts with rat EAAT1 protein. Cross-reactivity with human and mouse EAAT1 is predicted based on sequence homology.