Anti-Epidermal Growth Factor-like Protein 7 Antibody | QED Bioscience 90013 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Epidermal Growth Factor-like Protein 7 Antibody

catalog :

90013

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2H2

The same clone is also sold as:

Santa Cruz Biotechnology: sc-101349

reactivity :

human

product information

CATALOG NUMBER :

90013

PRODUCT NAME :

Anti-Epidermal Growth Factor-like Protein 7 Antibody

NAME+SKU :

Anti-Epidermal Growth Factor-like Protein 7 Antibody (90013)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Epidermal Growth Factor-like Protein 7 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Epidermal Growth Factor-like Protein 7

SPECIES REACTIVITY :

Human

TARGET NAME :

Epidermal Growth Factor-like Protein 7

UNIPROT :

Q9UHF1

LOCATION :

Secreted, extracellular space

PROTEIN NAME :

Epidermal growth factor-like protein 7

ALTERNATIVE NAMES :

EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7, NOTCH4-like protein, Vascular endothelial statin, VE-statin, Zneu1

GENE NAME :

EGFL7

CLONALITY :

Monoclonal

FORM :

Lyophilized

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

348.6

SKU SIZE 1 :

90013

APPLICATIONS :

WB, IHC, ELISA

APPLICATION INSTRUCTIONS :

ELISA: use at 1-10ug/ml. Immunoblotting: use at 1-5ug/ml. A band of ~30kDa is detected. Immunohistochemistry: Use at 2- 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

2H2

IMMUNOGEN :

His-tagged EGFL-7 recombinant protein. Accession no. Q9UHF1.

RESEARCH AREA :

Growth Factors, Cytokines, Receptors

FORMULATION :

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.

BUFFER :

Tris Buffer

TARGET BACKGROUND :

EGF-L7 (Epidermal Growth Factor Like Protein 7) is a multi-domain protein containing two EGF like domains and one EMI domain. It is expressed almost exclusively in endothelial cells and functions to promote normal development of the vascular system. EGF-L7 is capable of antagonistic binding to Notch receptors resulting in the inhibition of Notch signaling in HUVEC and neural stem cells. In research models inducing hypoxia and subsequent reoxygenation, (H/R), EGF- L7 can inhibit ICAM-1 expression and enhance the inhibition of NF-kappaB activation. Additionally, EGF-L7 is a chemoattractant for endothelial cells and binds to the extracellular matrix. The overexpression of EGF-L7 is observed in various cancers, and is generally correlated with increased metastasis and a poor prognosis.

FUNCTION :

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. {PubMed:23386126, PubMed:23639441}.

STORAGE CONDITION :

This antibody is stable for 1 month at 4°C or one year at -20°C. Avoid multiple freeze-thaw cycles.

SPECIFICITY :

This antibody reacts with human EGFL- 7 protein.