Anti-CD46/Membrane Cofactor Protein Antibody | QED Bioscience 90004 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-CD46/Membrane Cofactor Protein Antibody

catalog :

90004

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3F1

The same clone is also sold as:

OriGene: AM10193PU-N

reactivity :

human

product information

CATALOG NUMBER :

90004

PRODUCT NAME :

Anti-CD46/Membrane Cofactor Protein Antibody

NAME+SKU :

Anti-CD46/Membrane Cofactor Protein Antibody (90004)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-CD46/Membrane Cofactor Protein Mouse Monoclonal Antibody

SPECIFICITY SHORT :

CD46/Membrane Cofactor Protein

SPECIES REACTIVITY :

Human

TARGET NAME :

CD46/Membrane Cofactor Protein

UNIPROT :

P15529

LOCATION :

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane

PROTEIN NAME :

Membrane cofactor protein

ALTERNATIVE NAMES :

TLX, Trophoblast leukocyte common antigen, CD antigen CD46

GENE NAME :

CD46

CLONALITY :

Monoclonal

FORM :

Lyophilized

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

348.6

SKU SIZE 1 :

90004

APPLICATIONS :

WB, IHC, ELISA

APPLICATION INSTRUCTIONS :

Immunohistochemistry: use at 1- 10ug/ml. Immunoblotting: use at 0.5-1ug/ml. A band of ~44kDa is detected. Additional bands due to glycosylation of CD46 may be detected. ELISA: use at 0.1-1ug/ml with human CD46 on the solid phase. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

3F1

IMMUNOGEN :

Recombinant human CD46.

RESEARCH AREA :

Growth Factors, Cytokines, Receptors

FORMULATION :

Lyophilized in PBS.

BUFFER :

Phosphate Buffered Saline

TARGET BACKGROUND :

CD46 / Membrane Cofactor Protein is a type I membrane protein and is a regulatory part of the complement system; it has cofactor activity for inactivation of complement components C3b and C4b by serum factor I which protects the host cell from damage by complement. This protein also acts as a receptor for the Edmonston strain of measles virus, human Herpes virus-6 (HHV-6), and type IV pili of pathogenic Neisseria. Of interest is that medulloblastoma (a malignant brain tumor common in childhood) specimens express a high level of CD46.

FUNCTION :

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. {PubMed:10843656, PubMed:12540904}.; (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. {PubMed:12915534, PubMed:14566335, PubMed:15047806, PubMed:15078926, PubMed:15919905, PubMed:16254377}.; (Microbial infection) Acts as a receptor for cultured Measles virus. {PubMed:10972291}.; (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. {PubMed:12663806, PubMed:12724329}.; (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

STORAGE CONDITION :

This antibody is stable for 1 month at 4°C or one year at -20°C. Avoid multiple freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human CD46.

Image Name_1 :

qed-bioscience-anti-cd46-membrane-cofactor-protein-antibody-90004-1.jpg

Applications 1 :

IHC