Anti-Annexin A1 Antibody | QED Bioscience 90002 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Annexin A1 Antibody

catalog :

90002

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A1A7

reactivity :

human, bovine

product information

CATALOG NUMBER :

90002

PRODUCT NAME :

Anti-Annexin A1 Antibody

NAME+SKU :

Anti-Annexin A1 Antibody (90002)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Annexin A1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Annexin A1

SPECIES REACTIVITY :

Human, bovine

TARGET NAME :

Annexin A1

UNIPROT :

P04083

LOCATION :

Nucleus , Cytoplasm , Cell projection, cilium , Cell membrane , Membrane , Endosome membrane , Basolateral cell membrane , Apical cell membrane , Lateral cell membrane , Secreted , Secreted, extracellular space , Cell membrane , Secreted, extracellular exosome , Cytoplasmic vesicle, secretory vesicle lumen , Cell projection, phagocytic cup , Early endosome , Cytoplasmic vesicle membrane

PROTEIN NAME :

Annexin A1

ALTERNATIVE NAMES :

Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35 [Cleaved into: Annexin Ac2-26]

GENE NAME :

ANXA1

CLONALITY :

Monoclonal

FORM :

Lyophilized

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

348.6

SKU SIZE 1 :

90002

APPLICATIONS :

WB, IP

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-10ug/ml. A band of ~39kDa is detected. Immunohistochemistry: use at 2- 20ug/ml. Immunoprecipitation: use at 1-2ug per 100-500ug of total protein. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG2b

CLONE ID :

A1A7

IMMUNOGEN :

Annexin 1 isolated from human neutrophils.

RESEARCH AREA :

Apoptosis

FORMULATION :

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose.

BUFFER :

Tris Buffer

TARGET BACKGROUND :

Annexin 1 belongs to a family of Ca(2+)- dependent phospholipid binding proteins which have molecular weights of approximately 35-40kDa and are localized on the cytosolic face of the plasma membrane. Annexin 1, an endogenous anti-inflammatory protein, has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, and apoptosis. Annexin 1 also possesses phosphorylation sites for important proliferative signaling molecules e.g., EGF receptor tyrosine kinase and PKC. This suggests that Annexin 1 may have a role in certain signaling pathways important in cancer. However, the exact mechanisms through which Annexin 1 exerts some or all of its effects are still not clearly understood, and may reveal important functions of Annexin 1 in tumorigenesis and cancer development.

FUNCTION :

Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {UniProtKB:P10107, UniProtKB:P19619, PubMed:17008549, PubMed:19625660, PubMed:2532504, PubMed:2936963, PubMed:8425544, PubMed:8557678}.; [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {PubMed:15187149, PubMed:22879591, PubMed:25664854}.

STORAGE CONDITION :

This product is stable for at least one (1) year at -20C to -70C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human and bovine Annexin 1.