Anti-Protein Tyrosine Phosphatase Receptor F (PTPRF) Antibody | QED Bioscience 56579 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Protein Tyrosine Phosphatase Receptor F (PTPRF) Antibody

catalog :

56579

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S165-38

The same clone is also sold as:

Novus Biologicals: NBP2-42172
OriGene: AM60045PU-N
Rockland Immunochemicals: 200-308-W57, 200-367-W57, 200-365-W57, 200-357-W57, 200-301-W57, 200-306-W57, 200-360-W57, 200-305-W57, 200-362-W57, 200-363-W57, 200-361-W57, 200-303-W57, 200-366-W57, 200-326-W57, 200-358-W57, 200-355-W57, 200-352-W57, 200-302-W57

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

56579

PRODUCT NAME :

Anti-Protein Tyrosine Phosphatase Receptor F (PTPRF) Antibody

NAME+SKU :

Anti-Protein Tyrosine Phosphatase Receptor F (PTPRF) Antibody (56579)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Protein Tyrosine phosphatase Receptor F (PTPRF) Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Protein Tyrosine phosphatase Receptor F (PTPRF)

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

Protein Tyrosine Phosphatase Receptor F (PTPRF)

UNIPROT :

P10586

LOCATION :

Membrane; Single-pass type I membrane protein.

PROTEIN NAME :

Receptor-type tyrosine-protein phosphatase F

ALTERNATIVE NAMES :

EC 3.1.3.48, Leukocyte common antigen related, LAR

GENE NAME :

PTPRF

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56579

APPLICATIONS :

WB, IF

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-5ug/ml. A band of ~85kDa is detected which represents the subunit containing transmembrane and intracellular domains. Immunofluorescence: use at 10ug/ml. These are recommended concentrations. Endusers should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by Protein G affinity chromatography.

ISOTYPE :

IgG2a

CLONE ID :

S165-38

IMMUNOGEN :

Fusion protein corresponding to aa 1315-1607 (cytoplasmic C-terminus) of human PTPRF. This sequence is 97

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.1% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

PTPRF, like other members of the protein tyrosine phosphatase (PTP) family, is a signaling molecule that regulates a variety of cellular processes. PTPRF possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and represents a receptor-type PTP. The extracellular region contains three Ig-like domains and nine non-Ig like domains similar to that of neural-cell adhesion molecule. PTPRF functions in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta- catenin signaling. An increased expression level of PTPRF has been found in the insulin- responsive tissue of obese, insulin-resistant individuals and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

FUNCTION :

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium that is identical to that used in the assay system.

STORAGE CONDITION :

This product is stable for at least one (1) year at -20C.

SPECIFICITY :

This antibody recognizes human, mouse, and rat PTPRF.

Image Name_1 :

qed-bioscience-anti-protein-tyrosine-phosphatase-receptor-f-ptprf-antibody-56579-1.png

Applications 1 :

Western Blot

Image Name_2 :

qed-bioscience-anti-protein-tyrosine-phosphatase-receptor-f-ptprf-antibody-56579-2.png

Applications 2 :

ICC

Image Name_3 :

qed-bioscience-anti-protein-tyrosine-phosphatase-receptor-f-ptprf-antibody-56579-3.png

Applications 3 :

ICC