Anti-Pan-QKI Antibody | QED Bioscience 56555 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Pan-QKI Antibody

catalog :

56555

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S147-6

The same clone is also sold as:

OriGene: AM60063PU-N
Novus Biologicals: NBP2-42196
Rockland Immunochemicals: 200-306-W79, 200-363-W79, 200-365-W79, 200-358-W79, 200-308-W79, 200-360-W79, 200-305-W79, 200-326-W79, 200-361-W79, 200-352-W79, 200-367-W79, 200-357-W79, 200-355-W79, 200-302-W79, 200-362-W79, 200-366-W79, 200-301-W79, 200-303-W79

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

56555

PRODUCT NAME :

Anti-Pan-QKI Antibody

NAME+SKU :

Anti-Pan-QKI Antibody (56555)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Pan-QKI Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Pan-QKI

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

Pan-QKI

UNIPROT :

Q96PU8

LOCATION :

Nucleus , Cytoplasm

PROTEIN NAME :

Protein quaking

ALTERNATIVE NAMES :

Hqk, HqkI

GENE NAME :

QKI

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56555

APPLICATIONS :

WB, IF

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-5ug/ml. A band of ~36-38kDa is detected. Immunofluorescence: use at 10ug/ml. These are recommended concentrations. Endusers should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by Protein G affinity chromatography.

ISOTYPE :

IgG2b

CLONE ID :

S147-6

IMMUNOGEN :

Fusion protein corresponding to aa 1-341 (full-length) of human QKI-5. This sequence is 100

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.1% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

QKI (also called Protein Quaking or HqkI) is an RNA binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability, and protein translation and is itself regulated by alternative splicing. QKI is expressed in the frontal cortex of brain; it is shown to be downregulated in the brains of schizophrenic patients.

FUNCTION :

RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {UniProtKB:Q9QYS9, PubMed:16641098, PubMed:23630077}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium that is identical to that used in the assay system.

STORAGE CONDITION :

This product is stable for at least one (1) year at -20C.

SPECIFICITY :

This antibody recognizes human, mouse, and rat QKI-5. It cross-reacts with QKI-6, QKI-7, and QKI-7b.

Image Name_1 :

qed-bioscience-anti-pan-qki-antibody-56555-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-pan-qki-antibody-56555-2.png

Applications 2 :

ICC

Image Name_3 :

qed-bioscience-anti-pan-qki-antibody-56555-3.png

Applications 3 :

Western Blot