Anti-Ataxin-1 Antibody | QED Bioscience 56550 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Ataxin-1 Antibody

catalog :

56550

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S76-8

The same clone is also sold as:

Novus Biologicals: NBP2-42186
Rockland Immunochemicals: 200-326-W69, 200-363-W69, 200-308-W69, 200-302-W69, 200-366-W69, 200-362-W69, 200-365-W69, 200-360-W69, 200-306-W69, 200-352-W69, 200-301-W69, 200-358-W69, 200-367-W69, 200-357-W69, 200-355-W69, 200-303-W69, 200-361-W69

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

56550

PRODUCT NAME :

Anti-Ataxin-1 Antibody

NAME+SKU :

Anti-Ataxin-1 Antibody (56550)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Ataxin-1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Ataxin-1

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

Ataxin-1

UNIPROT :

P54254

LOCATION :

Cytoplasm , Nucleus

PROTEIN NAME :

Ataxin-1

ALTERNATIVE NAMES :

Spinocerebellar ataxia type 1 protein homolog

GENE NAME :

Atxn1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56550

APPLICATIONS :

WB, IF

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-5ug/ml. A band of ~85kDa is detected. Immunofluorescence: use at 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by Protein G affinity chromatography.

ISOTYPE :

IgG2b

CLONE ID :

S76-8

IMMUNOGEN :

Synthetic peptide corresponding to aa 164-197 (ATTPSQRSQLEAYSTLLAN- MGSLSQAPGHKVEPP) of mouse Ataxin-1. This sequence is 100

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.1% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Ataxin-1 is a member of the ATXN1 protein family. It is a neurodegenerative disorder protein that is believed to play a role in metabolism of RNA. A mutation of Ataxin-1 causes spinocerebellar ataxia type-1 (SCA1), a progressive neurodegenerative disease that primarily affects Purjinke cells in the brain stem and cerebellum. Ataxin-1 is ubiquitously expressed except in brain where it is limited to populations of neurons.

FUNCTION :

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). May be involved in RNA metabolism (By similarity). In concert with CIC and ATXN1L, involved in brain development (PubMed:28288114). {UniProtKB:P54253, PubMed:28288114}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium that is identical to that used in the assay system.

STORAGE CONDITION :

This product is stable for at least one (1) year at -20C.

SPECIFICITY :

This antibody recognizes human, mouse, and rat Ataxin-1.

Image Name_1 :

qed-bioscience-anti-ataxin-1-antibody-56550-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-ataxin-1-antibody-56550-2.png

Applications 2 :

ICC

Image Name_3 :

qed-bioscience-anti-ataxin-1-antibody-56550-3.png

Applications 3 :

Western Blot